The Value of EXO1 Molecule in the Diagnosis and Prognosis of Cervical Cancer Patients
Objective To investigate the value of EXO1 molecule in diagnosis and prognosis of cervical cancer.Methods A total of 309 cervical cancer-associated datasets were downloaded from the TCGA database,and the role of the EXO1 mole-cule in cervical cancer development was analyzed using bioinformatics analysis methods such as constructing column charts,GSEA enrichment analysis,GO and KEGG enrichment analysis,and Spearman rank correlation coefficient analysis.Re-sults The differential expression analysis revealed a significant elevation of EXO1 expression in the tumor group compared to the normal control group(P＜0.01).Survival analysis indicated a lower overall survival rate in cervical cancer patients with high expression of EXO1 as opposed to those with low expression.Univariate analysis demonstrated the occurrence of cervi-cal cancer was related to N stage,primary treatment method,and EXO1 expression(P＜0.05).Enrichment analysis results demonstrated that gene sets related to signaling pathways such as epidermal cell differentiation,regulation of endocrine processes,and enzyme activation were enriched in patients with high expression of EXO1.Spearman correlation analysis un-covered a negative correlation between the expression of EXO1 and the abundance of macrophages,neutrophils,Th1 cells,Th17 cells,regulatory T cells,and B cells,while it exhibited a positive correlation with helper T cells and memory T cells(P＜0.05).Conclusion EXO1mayserveasapotentialtargetforthediagnosticstrategyofcervicalcancerpatients.Moreo-ver,it can also be considered as a potential prognostic biomarker and therapeutic target for cervical cancer.
国家科技期刊平台
NSTL
万方数据
