Optimization of Extraction Technology of Total Organic Acids from Picris hieracioides L.by Central Composite Design-Response Surface Method
Objective To optimize the extraction process of total organic acids from Picris hieracioides L..Methods Based on single factor test,the extraction process of total organic acids from Picris hieracioides L.was optimized by using central composite design-response surface method,with liquid-solid ratio,extraction time and ethanol volume fraction as inde-pendent variables,and extraction yield of total organic acids as dependent variable.Results The optimum ultrasonic extrac-tion process of total organic acids from Picris hieracioides L.was as follows:liquid material ratio 29 ∶ 1(mL·g-1),ethanol volume fraction 67%,and extraction time of 43 min.The verification experiment yielded a total organic acid extraction rate of(1.65±0.02)%(n=3,RSD=0.92%),which is close to the predicted value by the model.Conclusion The optimized extraction technology is simple,the process parameters are reliable,and the extraction effect is ideal,laying a foundation for the subsequent studies on total organic acids from Picris hieracioides L..
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