注射用烟酰胺与4种常用溶媒配伍后稳定性考察
Investigation on the Compatibility of Nicotinamide Injection with Four Commonly Used Solvents and Their Stabili-ty
朱贵娟 1李子薇 2魏娟 3严汝纯1
作者信息
- 1. 湖北医药学院附属人民医院妇科,湖北 十堰 442000
- 2. 湖北医药学院附属人民医院药学部,湖北 十堰 442000
- 3. 湖北医药学院附属人民医院药学部,湖北 十堰 442000;湖北医药学院武当特色中药研究湖北省重点实验室,湖北 十堰 442000
- 折叠
摘要
目的:探究注射用烟酰胺与 4 种常用溶媒配伍后的稳定性,为临床合理用药提供参考.方法:将注射用烟酰胺分别与葡萄糖氯化钠注射液、5%葡萄糖注射液、10%葡萄糖注射液、0.9%氯化钠注射液配伍,在不同时间点取样测定配伍液pH值、观察其外观,并检测烟酰胺含量,评估其稳定性.结果:24 h内配伍液均澄清透明,无沉淀及变色.配伍液pH值均无显著变化,24 h内含量变化较为稳定.结论:注射用烟酰胺与葡萄糖氯化钠注射液、5%葡萄糖注射液、0.9%氯化钠注射液、10%葡萄糖注射液 4 种溶媒配伍后 24h内配伍液的pH、外观、相对百分含量均无显著变化,稳定性高,可作为溶媒使用.
Abstract
Objective To explore the compatibility of nicotinamide injection with four commonly used solvents and their sta-bility,to provide a reference for rational clinical medication.Methods Nicotinamide injection was combined separately with glucose and sodium chloride injection,5%dextrose injection,10%dextrose injection,and 0.9%sodium chloride injection.Samples were taken at various time points to measure their pH,appearance,and nicotinamide content for assessing the sta-bility.Results Within 24 hours,all combined solutions remained clear and transparent,without precipitation or discolora-tion observed,and there were no changes in their pH and nicotinamide content.Conclusion No significant changes were found in the pH,appearance,or relative percentage content of the four combined solutions over 24 hours,demonstrating high stability,which can be used as solvent.
关键词
注射用烟酰胺/配伍/稳定性/高效液相色谱法Key words
Nicotinamide injection/Compatibility/Stability/High-performance liquid chromatography(HPLC)引用本文复制引用
基金项目
十堰市科学技术研究与开发项目(22Y68)
湖北陈孝平科技发展基金会临床研究基金(CXPJJH12000005-07-54)
出版年
2024
国家科技期刊平台
NSTL
万方数据