Investigation on the Compatibility of Nicotinamide Injection with Four Commonly Used Solvents and Their Stabili-ty
Objective To explore the compatibility of nicotinamide injection with four commonly used solvents and their sta-bility,to provide a reference for rational clinical medication.Methods Nicotinamide injection was combined separately with glucose and sodium chloride injection,5%dextrose injection,10%dextrose injection,and 0.9%sodium chloride injection.Samples were taken at various time points to measure their pH,appearance,and nicotinamide content for assessing the sta-bility.Results Within 24 hours,all combined solutions remained clear and transparent,without precipitation or discolora-tion observed,and there were no changes in their pH and nicotinamide content.Conclusion No significant changes were found in the pH,appearance,or relative percentage content of the four combined solutions over 24 hours,demonstrating high stability,which can be used as solvent.
国家科技期刊平台
NSTL
万方数据
