纤维蛋白原与特发性膜性肾病患者肾小管萎缩/间质纤维化的关系及预测价值
Relationship Between Fibrinogen and Renal Tubular Atrophy/Interstitial Fibrosis in Patients with Idiopathic Membranous Nephropathy and the Predictive Value
黄亚楠 1张庆红 1史秀岩 1胡雪梅1
作者信息
- 1. 湖北医药学院附属太和医院肾病内科,湖北 十堰 442000
- 折叠
摘要
目的:探讨纤维蛋白原(FIB)与特发性膜性肾病(IMN)患者肾小管萎缩/间质纤维化(TA/IF)之间的关系及预测价值.方法:本研究纳入 2018 年 9 月至 2023 年 12 月在湖北医药学院附属太和医院肾病内科经肾活检证实的 171 例IMN患者,收集肾活检时的各项临床参数.根据肾穿刺活检前的FIB水平将患者分为正常FIB组(FIB≤4 g/L)和高FIB组(FIB＞4 g/L).根据TA/IF的程度,患者分为T1 组(无/轻度,n=67)、T2 组(中度,n=56)、T3组(重度,n=48).通过有序Logistic回归对TA/IF程度的影响因素进行分析.采用受试者工作特征(ROC)曲线分析FIB对TA/IF程度的预测价值.结果:与正常FIB组相比,高FIB组中、重度TA/IF的比例明显较高;T2 和T3 组患者的临床表现更差.年龄、FIB、TG是影响IMN患者TA/IF程度的独立危险因素;FIB对中重度TA/IF预测价值较好.结论:合理控制FIB水平可能减少IMN患者中重度TA/IF发生的风险.
Abstract
Objective To explore the relationship between fibrinogen(FIB)and renal tubular atrophy/interstitial fibrosis(TA/IF)in patients with idiopathic membranous nephropathy(IMN),and to evaluate the predictive value.Methods A to-tal of 171 IMN patients,diagnosed by renal biopsy at Taihe hospital,affiliated with Hubei University of Medicine from Sep-tember 2018 to December 2023 were included,and their clinical parameters were collected at the time of their biopsy.Based on FIB before biopsy,the patients were divided into a normal FIB group(FIB≤4 g/L)and a high FIB group(FIB＞4 g/L).Depending on the severity of TA/IF,the patients were further categorized into three groups:T1(none/mild,n=67),T2(moderate,n=56),and T3(severe,n=48).Ordered logistic regression was used to analyze the factors influen-cing the severity of TA/IF,while the predictive value of FIB for the severity of TA/IF was assessed using the receiver oper-ating characteristic(ROC)curve.Results Compared with the normal FIB group,the high FIB group had a significantly higher proportion of moderate-to-severe TA/IF;clinical manifestations were worse in patients within the T2 and T3 groups;age,FIB,and triglycerides(TG)emerged as independent risk factors for the severity of TA/IF in IMN patients,with FIB displaying notable predictive value for moderate-to-severe cases of TA/IF.Conclusion Reasonable control of FIB may reduce the risk of developing moderate-to-severe TA/IF in IMN patients.
关键词
纤维蛋白原/特发性膜性肾病/肾小管萎缩/间质纤维化Key words
Fibrinogen/Ldiopathic membranous nephropathy/Renal tubular atrophy/interstitial fibrosis引用本文复制引用
出版年
2024
国家科技期刊平台
NSTL
万方数据