Relationship Between Fibrinogen and Renal Tubular Atrophy/Interstitial Fibrosis in Patients with Idiopathic Membranous Nephropathy and the Predictive Value
Objective To explore the relationship between fibrinogen(FIB)and renal tubular atrophy/interstitial fibrosis(TA/IF)in patients with idiopathic membranous nephropathy(IMN),and to evaluate the predictive value.Methods A to-tal of 171 IMN patients,diagnosed by renal biopsy at Taihe hospital,affiliated with Hubei University of Medicine from Sep-tember 2018 to December 2023 were included,and their clinical parameters were collected at the time of their biopsy.Based on FIB before biopsy,the patients were divided into a normal FIB group(FIB≤4 g/L)and a high FIB group(FIB＞4 g/L).Depending on the severity of TA/IF,the patients were further categorized into three groups:T1(none/mild,n=67),T2(moderate,n=56),and T3(severe,n=48).Ordered logistic regression was used to analyze the factors influen-cing the severity of TA/IF,while the predictive value of FIB for the severity of TA/IF was assessed using the receiver oper-ating characteristic(ROC)curve.Results Compared with the normal FIB group,the high FIB group had a significantly higher proportion of moderate-to-severe TA/IF;clinical manifestations were worse in patients within the T2 and T3 groups;age,FIB,and triglycerides(TG)emerged as independent risk factors for the severity of TA/IF in IMN patients,with FIB displaying notable predictive value for moderate-to-severe cases of TA/IF.Conclusion Reasonable control of FIB may reduce the risk of developing moderate-to-severe TA/IF in IMN patients.
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