Assessment of Left Ventricular Stiffness Using Anterior Mitral Flow Velocity Combined with Longitudinal Dis-placement of Mitral Annulus by Shear Wave Elastography During Atrial Systole
Objective To investigate the feasibility of anterior mitral flow velocity combined with the longitudinal displace-ment of mitral annulus during atrial systole to assess left ventricular stiffness.Methods A total of 117 volunteers who under-went transthoracic echocardiography at the outpatient clinic were enrolled.Conventional echocardiographic parameters were measured,and the velocity-time integral(VTI)of the tissue Doppler a-wave,denoted as VTIa',was calculated to derive A2/VTIa'.Subjects were categorized into three groups:normal diastolic function group(GROUP 1,n=35),grade Ⅰ dias-tolic dysfunction group(GROUP 2,n=61),and grade Ⅱ&Ⅲ diastolic dysfunction group(GROUP 3,n=21).The differences in A2/VTIa' and other parameters among the groups were analyzed alongside correlational assessments with known stiffness parameters and influencing factors of stiffness.GROUP 1 and GROUP 2 were collectively termed the normal stiffness group(NS),and GROUP 3 was designated as the abnormal stiffness group(AS)to analyze the diagnostic per-formance of A2/VTIa'.Results Significant differences in A2/VTIa'were observed across the groups(P<0.001).A2/VTIa'exhibited a moderate-to-low positive correlation with LVEDP/LVEDV and KLV(r=0.411,0.222,P<0.05),a low posi-tive correlation with age,systolic blood pressure,and E/e'(r=0.364,0.338,0.356,P<0.001),and a negative correla-tion with e'(r=-0.365,P<0.001).The AUC of A2/VTIa' for distinguishing AS from NS was 0.805,with a diagnostic sensitivity of 81.0％and specificity of 66.7％.Conclusion A2/VTIa' proves to be a valuable measurement for evaluating left ventricular stiffness.Its diagnostic utility in identifying abnormal stiffness surpasses that of existing left ventricular stiff-ness assessment methods.
Atrial systole periodLeft ventricular stiffnessVelocity time integralAnterior mitral flow velocityLongitu-dinal motion of the mitral annulus
国家科技期刊平台
NSTL
万方数据
