Correlation Between Serum 25-hydroxyvitamin D3 and Carotid Intima-media Thickness and Atherosclerotic Plaque in Newly Diagnosed Type 2 Diabetes Mellitus Patients
Objective To investigate the correlation between 25-hydroxyvitamin D3[25-(OH)D3]and carotid intima-media thickness(IMT)and atherosclerotic plaque in newly diagnosed type 2 diabetes mellitus(T2DM)patients.Methods Fasting blood glucose(FBG),triglycerides(TG),total cholesterol(TC),low-density lipoprotein cholesterol(LDL-C),high-density lipoprotein cholesterol(HDL-C),and 25-(OH)D3 were measured in 206 newly diagnosed T2DM patients.Vascular ultrasound was used to assess IMT and carotid atherosclerotic plaque.Results Patients with atherosclerotic plaques had higher age,history of hypertension,LDL-C,HbA1c,and IMT compared with those without plaques(P＜0.05),while the 25-(OH)D3 was lower in the plaque group(P＜0.05).Spearman correlation analysis indicated that ca-rotid IMT had a positive correlation with smoking history(rs=0.124,P=0.038)and history of hypertension(rs=0.175,P=0.001).Pearson correlation analysis revealed that carotid IMT was positively correlated with age,HbA1c,and LDL-C(all P＜0.05),and negatively correlated with 25-(OH)D3 and blood calcium(both P＜0.05).Logistic regression analysis showed that age,HbA1c,LDL-C,and history of hypertension were risk factors for the development of carotid atheroscle-rotic plaque,and 25-(OH)D3 directly affected plaque formation.Conclusion 25-(OH)D3 is inversely associated with carotid IMT in newly diagnosed T2DM patients,and low 25-(OH)D3 may be a potential risk factor for carotid atheroscle-rosis formation.
Type 2 diabetes mellitus25-Hydroxyvitamin D3Carotid intima-media thicknessAtherosclerotic plaque
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