Prognosis and Drug Sensitivity of Cuproptosis-related Gene CDKN2A in Head and Neck Squamous Cell Carcino-ma
Objective To identify cuproptosis-related genes associated with prognosis in head and neck squamous cell carci-noma(HNSCC)and analyze their drug sensitivity.Methods Mutant genes in HNSCC samples obtained from the TCGA da-tabase were screened to select cuproptosis-related genes for drug sensitivity and resistance analysis.Results Among the 23 genes with a mutation rate of 10%or above in HNSCC,CDKN2A,CSMD3,and RYR2 were identified as key genes.Among the 13 cuproptosis-related genes,CDKN2A,GLS,and ATP7B were identified as key genes associated with prognosis.Drugs sensitive to the CDKN2A in HNSCC included Thapsigargin,ACY-1215(Rocilinostat),and Trichostatin A,while drugs with high resistance included Palbociclib,Nutlin-3a,Platin,SJ-172550,carbazochrome,and bambuterol.Conclu-sion CDKN2A is highly correlated with the 5-year survival of HNSCC and is sensitive to anti-tumor drugs Thapsigargin,ACY-1215(Rocilinostat),and Trichostatin A.
CuproptosisHead and neck squamous cell carcinomaCDKN2A
万方数据
维普
