Association Between Serum 3-Carboxy-4-Methyl-5-Propyl-2-Furanpropanoic Acid ( CMPF) and Insulin Resistance in Patients with Abnormal Glucose Metabolism
Objective To analyze the relationship between serum 3-carboxy-4-methyl-5-propyl-2-furanpropanoic acid ( CMPF) and insulin resistance in patients with different glucose metabolism.Methods The established diabetes screening database of permanent residents in Shanghai was selected for analysis.The newly diagnosed T2DM patients ( T2DM group),residents with normal glucose tolerance ( NGT group) and those with impaired glucose regulation ( IGR group) were includ-ed according to gender,age,and body mass index,100 in each group.Serum CMPF was determined by enzyme-linked im-munosorbent assay.The relationship between CMPF and insulin resistance was analyzed using statistical methods.Results CMPF increased gradually in the NGT group,IGR group,and T2DM group.Homeostasis model assessment of insulin re-sistance index ( HOMA-IR) in the T2DM and IGR groups was higher than that in the NGT group.Homeostasis model as-sessment of beta-cell function ( HOMA-β),first-phase insulin secretion,second-phase insulin secretion,DI30,and DI120 decreased successively in the three groups ( all P<0.001) .Pearson correlation analysis showed that serum CMPF was positively correlated with HOMA-IR ( P<0.05),and negatively correlated with HOMA-β,first-phase insulin secretion,and DI30 ( P<0.05) .The binary logistic regression revealed that serum CMPF was associated with the progressive exacerba-tion of insulin resistance after adjusting for gender,age,and body mass index[OR=2.743 (1.553,4.846),P<0.001].Conclusion CMPF differed in people with different glucose metabolism.It increased in people with abnormal glucose me-tabolism and was positively correlated with insulin resistance.However,further research is needed to clarify the potential causal link.
万方数据
维普
