达格列净对2型糖尿病减轻肾损害及炎症作用的临床观察
The Clinical Observation of Dapagaliflozin on Reducing Renal Damage and Inflammation in Type 2 Diabetes
王煜 1周荣 2刘珊3
作者信息
- 1. 岳阳职业技术学院 基础医学部,湖南 岳阳 414000
- 2. 岳阳市东茅岭社区医疗服务中心 内科,湖南 岳阳 414000
- 3. 岳阳市中心医院 内分泌科,湖南 岳阳 414000
- 折叠
摘要
目的 观察达格列净对早期 2 型糖尿病肾病(DN)患者肾功能和尿微量白蛋白的影响,探讨其与患者血清促炎症因子变化的关系.方法 纳入 30 例初诊 2 型糖尿病、50 例早期DN患者与 30 例正常对照(NGT).2 型糖尿病组和DN组口服达格列净治疗>12 周,观察其疗效、肾功能和血清促炎症因子的变化.结果 治疗后,2 型糖尿病组和DN组空腹血糖和糖化血红蛋白下降,体重和血压均有下降(P<0.05);两组的肾小球滤过率有所下降(P<0.05);DN组的尿白蛋白/肌酐比值降低(P<0.05);糖尿病患者较正常对照组血清促炎症因子增加,而治疗后单核细胞趋化因子-1、白细胞介素-6 和肿瘤坏死因子-α水平降低(P<0.05).结论 达格列净能改善早期DN患者的尿蛋白漏出,除降糖、降压和减重外,该作用可能与促炎症因子水平的降低直接有关.
Abstract
Objective:To investigate the effects of Dapagliflozin on renal functions and urine microalbumin in diabetic nephropathy(DN)patients,and discuss the association between the effects and serum pro-inflammatory cytokines level.Methods:Thirty patients with new onset type 2 diabetes mellitus and 50 patients with diabetic nephropathy were treated with dapagliflozin for above 12 weeks.Thirty healthy subjects were involved in as normal control.The clinical effects,renal functions and serum pro-inflammatory cytokines were analyzed.Results:After 8 weeks treatment,the FBG and HbA1c in the type 2 diabetes mellitus and DN groups decreased(P<0.05).The body weight and blood pressures also reduced.The values of eGFR decreased in the two groups(P<0.05).The level of the urinary albumin/creatinine ratio(UACR)significantly decreased in DN group(P<0.05).The serum pro-inflammatory cytokines levels increased in type 2 diabetes mellitus patients.The levels of serum MCP-1,IL-6,and TNF-α significantly reduced after dapagliflozin therapy(P<0.05).Conclusion:Dapagliflozin can ameliorate the leakage of urinary albumin in DN patients,and in addition to glucose reduction,blood pressure reduction,and weight loss,this effect may be directly related to a reduction in pro-inflammatory factor levels.
关键词
达格列净/糖尿病肾病/促炎症因子Key words
Dapagliflozin/diabetic nephropathy/pro-inflammatory cytokines引用本文复制引用
出版年
2024
NETL
NSTL
维普
万方数据