The Clinical Observation of Dapagaliflozin on Reducing Renal Damage and Inflammation in Type 2 Diabetes
Objective:To investigate the effects of Dapagliflozin on renal functions and urine microalbumin in diabetic nephropathy(DN)patients,and discuss the association between the effects and serum pro-inflammatory cytokines level.Methods:Thirty patients with new onset type 2 diabetes mellitus and 50 patients with diabetic nephropathy were treated with dapagliflozin for above 12 weeks.Thirty healthy subjects were involved in as normal control.The clinical effects,renal functions and serum pro-inflammatory cytokines were analyzed.Results:After 8 weeks treatment,the FBG and HbA1c in the type 2 diabetes mellitus and DN groups decreased(P<0.05).The body weight and blood pressures also reduced.The values of eGFR decreased in the two groups(P<0.05).The level of the urinary albumin/creatinine ratio(UACR)significantly decreased in DN group(P<0.05).The serum pro-inflammatory cytokines levels increased in type 2 diabetes mellitus patients.The levels of serum MCP-1,IL-6,and TNF-α significantly reduced after dapagliflozin therapy(P<0.05).Conclusion:Dapagliflozin can ameliorate the leakage of urinary albumin in DN patients,and in addition to glucose reduction,blood pressure reduction,and weight loss,this effect may be directly related to a reduction in pro-inflammatory factor levels.
NETL
NSTL
万方数据
维普
