To Study the effect of mulberry leaf polysaccharides on anti-fatigue in mice was analyzed by weight-bearing swimming test of mice and related physiological indicators.The results showed that taking a certain a-mount of mulberry leaf polysaccharides significantly prolonged exhaustion time of weight-bearing swimming,re-duced the content of lactic acid,urea nitrogen and malondialdehyde in mice,enhanced the storage capacity of muscle glycogen and hepatic glycogen,increased the content of lactate dehydrogenase,superoxide dismutase and glutathione peroxidase,and total antioxidant capacity,up-regulated the gene expression of PGC-1α,NRF-1 and TFAM,and also improved the damage to myocardial cells and liver cells caused by fatigue.
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