Pharmacological actions of the bioactive compounds of Epimedium on the male reproductive system:current status and future perspective

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外文摘要：Compounds isolated from Epimedium include the total flavonoids of Epimedium,icariin,and its metabolites(icaritin,icarisideⅠ,and icariside Ⅱ),which have similar molecular structures.Modern pharmacological research and clinical practice have proved that Epimedium and its active components have a wide range of pharmacological effects,especially in improving sexual function,hormone regulation,anti-osteoporosis,immune function regulation,anti-oxidation,and anti-tumor activity.To date,we still need a comprehensive source of knowledge about the pharmacological effects of Epimedium and its bioactive compounds on the male reproductive system.However,their actions in other tissues have been reviewed in recent years.This review critically focuses on the Epimedium,its bioactive compounds,and the biochemical and molecular mechanisms that modulate vital pathways associated with the male reproductive system.Such intrinsic knowledge will significantly further studies on the Epimedium and its bioactive compounds that protect the male reproductive system and provide some guidances for clinical treatment of related male reproductive disorders.

外文关键词：

Epimediumicariininfertilitymale reproductive systemtumor

作者：

Song-Po Liu、Yun-Fei Li、Dan Zhang、Chun-Yang Li、Xiao-Fang Dai、Dong-Feng Lan、Ji Cai、He Zhou、Tao Song、Yan-Yu Zhao、Zhi-Xu He、Jun Tan、Ji-Dong Zhang

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作者单位：

Department of Immunology,Zunyi Medical University,Zunyi 563000,China

Special Key Laboratory of Gene Detection and Therapy of Guizhou Province,Zunyi Medical University,Zunyi 563000,China

Department of Medical Genetics,Zunyi Medical University,Zunyi 563000,China

Department of Respiratory Medicine,The Third Affiliated Hospital of Zunyi Medical University(The First People's Hospital of Zunyi),Zunyi 563000,China

Zunyi Medical University Library,Zunyi 563000,China

Collaborative Innovation Center of Tissue Damage Repair and Regeneration Medicine,Zunyi Medical University,Zunyi 563000,China

Department of Histology and Embryology,Zunyi Medical University,Zunyi 563000,China

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出版年：

2025

DOI：

10.4103/aja20248

亚洲男性学杂志(英文版)

中国科学院上海药物研究所

亚洲男性学杂志(英文版)

影响因子：0.514

ISSN：1008-682X

年,卷(期)：2025.27(1)