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亚洲男性学杂志（英文版）
亚洲男性学杂志（英文版）

王一飞

双月刊

1008-682X

aja@sibs.ac.cn，aja@mail.shcnc.an.cn

021-54922824

200031

上海市太原路294号16号楼302室

亚洲男性学杂志（英文版）/Journal Asian Journal of AndrologyCSCDCSTPCD北大核心SCI
查看更多>>本刊主要刊登男科、泌尿科学及男性生殖健康等相关领域的创新基础研究和临床成果，旨在促进全球范围的学术传播，加强中国男科学专家与国际的学术交流和合作。
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    Divergences in neuroendocrine prostate cancer frequency as recognized by anatomic pathologists,clinicians,and basic scientists

    Kenneth A IczkowskiMamta Parikh
    1-3页
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    Gene regulation and signaling transduction in mediating the self-renewal,differentiation,and apoptosis of spermatogonial stem cells

    Cai-Mei HeDong ZhangZuping He
    4-12页
    查看更多>>摘要：Infertility has become one of the most serious diseases worldwide,and 50％of this disease can be attributed to male-related factors.Spermatogenesis,by definition,is a complex process by which spermatogonial stem cells(SSCs)self-renew to maintain stem cell population within the testes and differentiate into mature spermatids.It is of great significance to uncover gene regulation and signaling pathways that are involved in the fate determinations of SSCs with aims to better understand molecular mechanisms underlying human spermatogenesis and identify novel targets for gene therapy of male infertility.Significant achievement has recently been made in demonstrating the signaling molecules and pathways mediating the fate decisions of mammalian SSCs.In this review,we address key gene regulation and crucial signaling transduction pathways in controlling the self-renewal,differentiation,and apoptosis of SSCs,and we illustrate the networks of genes and signaling pathways in SSC fate determinations.We also highlight perspectives and future directions in SSC regulation by genes and their signaling pathways.This review could provide novel insights into the genetic regulation of normal and abnormal spermatogenesis and offer molecular targets to develop new approaches for gene therapy of male infertility.
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    Role of pericytes in regulating penile angiogenesis and nerve regeneration

    Guo Nan YinJi-Kan Ryu
    13-19页
    查看更多>>摘要：Pericytes are multifunctional mural cells that surround the abluminal wall of endothelial cells and are associated with vascular development,vascular permeability,and angiogenesis.Additionally,pericytes demonstrate stem cell-like properties and contribute to neuroinflammatory processes.Pericytes have been extensively studied in the central nervous system.However,specific mechanisms underlying its involvement in various physiological and pathological conditions,especially in erectile dysfunction(ED),remain poorly understood.Advancements in in vitro and in vitro techniques,such as single-cell RNA sequencing,are expanding our understanding of pericytes.Recent studies have shown that pericyte dysfunction is considered an important factor in the pathogenesis of vascular and neurological ED.Therefore,this study aims to analyze the specific role of pericytes in ED,focusing on diabetic and neurogenic ED.This article provides a comprehensive review of research findings on PubMed from 2000 to 2023,concerning pericyte dysfunction in the process of ED,offering valuable insights,and suggesting directions for further research.
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    Pharmacological actions of the bioactive compounds of Epimedium on the male reproductive system:current status and future perspective

    Song-Po LiuYun-Fei LiDan ZhangChun-Yang Li...
    20-29页
    查看更多>>摘要：Compounds isolated from Epimedium include the total flavonoids of Epimedium,icariin,and its metabolites(icaritin,icarisideⅠ,and icariside Ⅱ),which have similar molecular structures.Modern pharmacological research and clinical practice have proved that Epimedium and its active components have a wide range of pharmacological effects,especially in improving sexual function,hormone regulation,anti-osteoporosis,immune function regulation,anti-oxidation,and anti-tumor activity.To date,we still need a comprehensive source of knowledge about the pharmacological effects of Epimedium and its bioactive compounds on the male reproductive system.However,their actions in other tissues have been reviewed in recent years.This review critically focuses on the Epimedium,its bioactive compounds,and the biochemical and molecular mechanisms that modulate vital pathways associated with the male reproductive system.Such intrinsic knowledge will significantly further studies on the Epimedium and its bioactive compounds that protect the male reproductive system and provide some guidances for clinical treatment of related male reproductive disorders.
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    In vitro effects of antidepressants on human sperm function

    Rita António SantosAna Paula SousaTeresa Almeida-SantosJoão Ramalho-Santos...
    30-36页
    查看更多>>摘要：Depression currently affects about 280 million people worldwide and its prevalence has been increasing dramatically,especially among the young and people of reproductive age,which consequently leads to an increase in antidepressant consumption.Antidepressants are associated with sexual dysfunction in both men and women;however,their role in male fertility has been scarcely studied.Fluoxetine and sertraline,two serotonin reuptake inhibitors(SSRIs),are among the most prescribed antidepressants worldwide.To determine their possible effects,human sperm cells were exposed to either sertraline or fluoxetine at concentrations previously found in blood and seminal fluid of patients undergoing treatment.Spermatozoa were incubated for up to 24 h at 37℃ and 5％CO2,and important functional parameters such as sperm motility,viability,mitochondrial membrane potential,cellular reactive oxygen species(ROS)production,chromatin/DNA integrity,acrosome status,and tyrosine phosphorylation were assessed.At low levels,fluoxetine consistently decreased progressive motility throughout time while promoting fluctuations in ROS levels and sperm capacitation.Nevertheless,it did not affect viability,mitochondrial membrane potential,acrosome reaction nor chromatin/DNA integrity.Sertraline,on the other hand,had little to nonsignificant impact at low doses,but affected almost all tested parameters at supratherapeutic concentrations.Altogether,our results suggest that both antidepressants may impair sperm function,possibly through different mechanisms of action,but fluoxetine is the only exhibiting mild negative effects at doses found in vivo.
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    A behind-the-scenes role of BDNF in the survival and differentiation of spermatogonia

    Shin-ichi TomizawaKazushige KurohaMichio OnoKuniko Nakajima...
    37-43页
    查看更多>>摘要：Mouse spermatogenesis entails the maintenance and self-renewal of spermatogonial stem cells(SSCs),which require a complex web-like signaling network transduced by various cytokines.Although brain-derived neurotrophic factor(BDNF)is expressed in Sertoli cells in the testis,and its receptor tropomyosin receptor kinase B(TrkB)is expressed in the spermatogonial population containing SSCs,potential functions of BDNF for spermatogenesis have not been uncovered.Here,we generate BDNF conditional knockout mice and find that BDNF is dispensable for in vivo spermatogenesis and fertility.However,in vitro,we reveal that BDNF-deficient germline stem cells(GSCs)exhibit growth potential not only in the absence of glial cell line-derived neurotrophic factor(GDNF),a master regulator for GSC proliferation,but also in the absence of other factors,including epidermal growth factor(EGF),basic fibroblast growth factor(bFGF),and insulin.GSCs grown without these factors are prone to differentiation,yet they maintain expression of promyelocytic leukemia zinc finger(Plzf),an undifferentiated spermatogonial marker.Inhibition of phosphoinositide 3-kinase(PI3K),mitogen-activated protein kinase(MAPK)/extracellular signal-regulated kinase(ERK),and Src pathways all interfere with the growth of BDNF-deficient GSCs.Thus,our findings suggest a role for BDNF in maintaining the undifferentiated state of spermatogonia,particularly in situations where there is a shortage of growth factors.
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    The SPARC-related modular calcium binding 1(Smoc1)regulated by androgen is required for mouse gubernaculum development and testicular descent

    Zhi-Yi ZhaoYong SiowLing-Yun LiuXian Li...
    44-51页
    查看更多>>摘要：Testicular descent occurs in two consecutive stages:the transabdominal stage and the inguinoscrotal stage.Androgens play a crucial role in the second stage by influencing the development of the gubernaculum,a structure that pulls the testis into the scrotum.However,the mechanisms of androgen actions underlying many of the processes associated with gubernaculum development have not been fully elucidated.To identify the androgen-regulated genes,we conducted large-scale gene expression analyses on the gubernaculum harvested from luteinizing hormone/choriogonadotropin receptor knockout(Lhcgr KO)mice,an animal model of inguinoscrotal testis maldescent resulting from androgen deficiency.We found that the expression of secreted protein acidic and rich in cysteine(SPARC)-related modular calcium binding 1(Smoc1)was the most severely suppressed at both the transcript and protein levels,while its expression was the most dramatically induced by testosterone administration in the gubernacula of Lhcgr KO mice.The upregulation of Smoc1 expression by testosterone was curtailed by the addition of an androgen receptor antagonist,flutamide.In addition,in vitro studies demonstrated that SMOC1 modestly but significantly promoted the proliferation of gubernacular cells.In the cultures of myogenic differentiation medium,both testosterone and SMOC1 enhanced the expression of myogenic regulatory factors such as paired box 7(Pax7)and myogenic factor 5(Myf5).After short-interfering RNA-mediated knocking down of Smoc1,the expression of Pax7 and Myf5 diminished,and testosterone alone did not recover,but additional SMOC1 did.These observations indicate that SMOC1 is pivotal in mediating androgen action to regulate gubernaculum development during inguinoscrotal testicular descent.
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    Predictability of varicocele repair success:preliminary results of a machine learning-based approach

    Andrea CrafaMarco RussoRossella CannarellaMurat Gül...
    52-58页
    查看更多>>摘要：Varicocele is a prevalent condition in the infertile male population.However,to date,which patients may benefit most from varicocele repair is still a matter of debate.The purpose of this study was to evaluate whether certain preintervention sperm parameters are predictive of successful varicocele repair,defined as an improvement in total motile sperm count(TMSC).We performed a retrospective study on 111 patients with varicocele who had undergone varicocele repair,collected from the Department of Endocrinology,Metabolic Diseases and Nutrition,University of Catania(Catania,Italy),and the Unit of Urology at the Selcuk University School of Medicine(Konya,Türkiye).The predictive analysis was conducted through the use of the Brain Project,an innovative tool that allows a complete and totally unbiased search of mathematical expressions that relate the object of study to the various parameters available.Varicocele repair was considered successful when TMSC increased by at least 50％of the preintervention value.For patients with preintervention TMSC below 5 × 10 6,improvement was considered clinically relevant when the increase exceeded 50％and the absolute TMSC value was＞5 × 10 6.From the preintervention TMSC alone,we found a model that predicts patients who appear to benefit little from varicocele repair with a sensitivity of 50.0％and a specificity of 81.8％.Varicocele grade and serum follicle-stimulating hormone(FSH)levels did not play a predictive role,but it should be noted that all patients enrolled in this study were selected with intermediate-or high-grade varicocele and normal FSH levels.In conclusion,preintervention TMSC is predictive of the success of varicocele repair in terms of TMSC improvement in patients with intermediate-or high-grade varicoceles and normal FSH levels.
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    Delayed covering causes the accumulation of motile sperm,leading to overestimation of sperm concentration and motility with a Makler counting chamber

    Lin YuQing-Yuan ChengYe-Lin JiaYan Zheng...
    59-64页
    查看更多>>摘要：According to the World Health Organization(WHO)manual,sperm concentration should be measured using an improved Neubauer hemocytometer,while sperm motility should be measured by manual assessment.However,in China,thousands of laboratories do not use the improved Neubauer hemocytometer or method;instead,the Makler counting chamber is one of the most widely used chambers.To study sources of error that could impact the measurement of the apparent concentration and motility of sperm using the Makler counting chamber and to verify its accuracy for clinical application,67 semen samples from patients attending the Department of Andrology,West China Second University Hospital,Sichuan University(Chengdu,China)between 13 September 2023 and 27 September 2023,were included.Compared with applying the cover glass immediately,delaying the application of the cover glass for 5 s,10 s,and 30 s resulted in average increases in the sperm concentration of 30.3％,74.1％,and 107.5％,respectively(all P＜0.0001)and in the progressive motility(PR)of 17.7％,30.8％,and 39.6％,respectively(all P＜0.0001).However,when the semen specimens were fixed with formaldehyde,a delay in the application of the cover glass for 5 s,10 s,and 30 s resulted in an average increase in the sperm concentration of 6.7％,10.8％,and 14.6％,respectively,compared with immediate application of the cover glass.The accumulation of motile sperm due to delays in the application of the cover glass is a significant source of error with the Makler counting chamber and should be avoided.
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    Application of the modified Byars staged procedure for severe hypospadias repair

    Qi-Gen XieTing-Ting XueXu-Ren ChenZhao-Ying Li...
    65-71页
    查看更多>>摘要：This study aimed to introduce a modified Byars staged procedure and investigate its application value in patients with severe hypospadias.We retrospectively analyzed the clinical data of patients with severe hypospadias admitted to the First Affiliated Hospital of Sun Yat-sen University(Guangzhou,China)between October 2012 and October 2022.In total,31 patients underwent the conventional Byars procedure(conventional group),and 45 patients underwent the modified Byars staged procedure(modified group).Our modified strategy was built upon the standard Byars procedure by incorporating glansplasty during the first stage and employing a Y-shaped flap in conjunction with a glandular tunnel for urethroplasty during the second stage.Notably,there were no statistically significant differences in the preoperative baseline characteristics,duration of surgery,amount of blood loss,or occurrence of postoperative complications,including urethral fistula,stricture and diverticulum,or penile curvature,between the conventional and modified groups.However,there was a significantly lower incidence of coronal sulcus fistula(0 vs 16.1％,P=0.02)and glans dehiscence(0 vs 12.9％,P=0.02)in the surgical group than that in the conventional group.In addition,the modified group exhibited a notably greater rate of normotopic urethral opening(100.0％vs 83.9％,P=0.01)and a higher mean score on the Hypospadias Objective Penile Evaluation(HOPE;mean±standard error of mean:8.6±0.2 vs 7.9±0.3,P=0.02)than did the conventional group.In conclusion,the modified Byars staged procedure significantly reduced the risks of glans dehiscence and coronal sulcus fistula.Consequently,it offers a promising approach for achieving favorable penile esthetics,thereby providing a reliable therapeutic option for severe hypospadias.
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