首页|In vitro effects of antidepressants on human sperm function

In vitro effects of antidepressants on human sperm function

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Depression currently affects about 280 million people worldwide and its prevalence has been increasing dramatically,especially among the young and people of reproductive age,which consequently leads to an increase in antidepressant consumption.Antidepressants are associated with sexual dysfunction in both men and women;however,their role in male fertility has been scarcely studied.Fluoxetine and sertraline,two serotonin reuptake inhibitors(SSRIs),are among the most prescribed antidepressants worldwide.To determine their possible effects,human sperm cells were exposed to either sertraline or fluoxetine at concentrations previously found in blood and seminal fluid of patients undergoing treatment.Spermatozoa were incubated for up to 24 h at 37℃ and 5％CO2,and important functional parameters such as sperm motility,viability,mitochondrial membrane potential,cellular reactive oxygen species(ROS)production,chromatin/DNA integrity,acrosome status,and tyrosine phosphorylation were assessed.At low levels,fluoxetine consistently decreased progressive motility throughout time while promoting fluctuations in ROS levels and sperm capacitation.Nevertheless,it did not affect viability,mitochondrial membrane potential,acrosome reaction nor chromatin/DNA integrity.Sertraline,on the other hand,had little to nonsignificant impact at low doses,but affected almost all tested parameters at supratherapeutic concentrations.Altogether,our results suggest that both antidepressants may impair sperm function,possibly through different mechanisms of action,but fluoxetine is the only exhibiting mild negative effects at doses found in vivo.

fluoxetinehuman spermmale fertilitysertralinesperm functionSSRIs

Rita António Santos、Ana Paula Sousa、Teresa Almeida-Santos、João Ramalho-Santos、Renata Santos Tavares

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University of Coimbra,Institute for Interdisciplinary Research,Doctoral Programme in Experimental Biology and Biomedicine(PDBEB),Coimbra 3030-789,Portugal

Center for Neuroscience and Cell Biology,University of Coimbra(CNC-UC),Coimbra 3000-548,Portugal

Centre for Innovative Biomedicine and Biotechnology(CIBB),University of Coimbra,Coimbra 3000-548,Portugal

Reproductive Medicine Unit,Coimbra Hospital and University Centre(CHUC),Coimbra 3004-561,Portugal

Faculty of Medicine,University of Coimbra,Coimbra 3000-548,Portugal

Department of Life Sciences,University of Coimbra,Coimbra 3000-456,Portugal

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2025

10.4103/aja202459

亚洲男性学杂志(英文版)
中国科学院上海药物研究所

亚洲男性学杂志(英文版)

影响因子：0.514
ISSN：1008-682X
年,卷(期)：2025.27(1)