The function and structure of the radioactive material liquid sampling cabinet for spent fuel reprocessing was introduced,and the technical difficulties of the inner shell box and shielding layer in the sampling cabinet were analyzed,and the manufacturing process was proposed.The inner shell box of the sampling cabinet was divided into three parts such as bottom shell,top shell and middle shell,which are independently made,and then assembled and positioned for welding,and the tightness test was carried out.The proposed manufacturing process of the inner shell box and shield layer of the sampling cabinet can provide a reference for the manufacturing of similar spent fuel reprocessing tank.