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Application of Connectivity Map Database to Research on Chinese Materia Medica
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The connectivity map (CMAP) database is established initially to connect biology,chemistry,and clinical conditions,which helps to discover the connection of disease-gene-drug.The CMAP approach has been applied in the field of drug discovery and development,which is widely recognized.In recently years,CMAP analysis has been applied in the research on Chinese materia medica (CMM).The study of CMM is facing a wide range of challenges,such as complicated ingredients,multiple targets,multiple pathways of action and complex functioning mechanism.The idea of employing CMAP in the CMM research has brought a new perspective for researchers and provides a systematic method for elucidating the mechanism of CMM.
Chinese materia medicaChinese materia medica formulaconnectivity mapestablishing connectivity map database
Chao Lv、Yu-chong Wang、Run-hui Liu、Wei-dong Zhang
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School of Pharmacy,Second Military Medical University,Shanghai 200433,China
Shanghai Institute of Pharmaceutical Industry,China State Institute of Pharmaceutical Industry,Shanghai 201203,China
Professor of Chang Jiang Scholars Program,NSFCProfessor of Chang Jiang Scholars Program,NSFC
NETL
NSTL
万方数据
维普
