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中草药(英文版)
中草药(英文版)

季刊

1674-6384

chm@tiprpress.com;bjchm@tiprpress.com

022-23006901

300193

天津市南开区鞍山西道308号

中草药(英文版)/Journal Chinese Herbal MedicinesCSTPCD
正式出版
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    Integrating tradition and innovation:Health industry opportunities for ginseng with foods and medicines

    Wei Li
    487-488页

    Ginsenoside Rb1 in cardiovascular and cerebrovascular diseases:A review of therapeutic potentials and molecular mechanisms

    Yueqin SongChen ChenWei Li
    489-504页
    查看更多>>摘要:Cardiovascular and cerebrovascular diseases(CCVDs),which are circulatory system diseases caused by heart defects and vascular diseases,are the major noncommunicable diseases affecting global public health.With the improvement of economic level and the change of human lifestyle,the prevalence of CCVDs continues to increase.Ginseng(Panax ginseng C.A.Mey.)was widely used in traditional diseases due to its supposed tonic properties.Ginsenoside Rb1(G-Rb1)is the most abundant active ingredient with multiple pharmacological effects extracted from ginseng,which has been shown to have potential bene-fits on the cardiovascular system through a variety of mechanisms,including anti-oxidation,anti-inflammatory,regulation of vasodilation,reduction of platelet adhesion,influence of calcium ion chan-nels,improvement of lipid distribution,involving in glucose metabolism and controlling blood sugar.This review reviewed the protective effects of G-Rb1 on CCVDs and its potential mechanisms,such as atherosclerosis(AS),hypertension,coronary heart disease(CHD),ischemic stroke(IS)and periocular microvascular retinopathy.Finally,we reviewed and reported the results of in vivo and in vitro experi-ments using G-Rb1 to improve CCVDs,highlighted its efficacy,safety,and limitations.

    Phytochemistry,quality control and biosynthesis in ginseng research from 2021 to 2023:A state-of-the-art review concerning advances and challenges

    Mengxiang DingHuizhen ChengXiaohang LiXue Li...
    505-520页
    查看更多>>摘要:Panax L.(Araliaceae)has a long history of medicinal and edible use due to its significant tonifying effects,and ginseng research has been a hot topic in natural products research and food science.In continuation of our recent ginseng review,we highlighted the advances in ginseng research from 2021 to 2023 with 157 citations,which exhibited the increasingly systematic,collaborative,and intelligent characteristics.In this review,we firstly updated the progress in phytochemistry involving the ginsenosides and polysac-charides and summarized the researches on the active components.Then,some specific applications by feat of the multidimensional chromatography,mass spectrometry imaging,DNA barcoding,and metabo-lomics,were analyzed,which could provide rich information supporting the multi-component character-ization,authentication,and quality control of ginseng and the versatile products.Finally,the recent biosynthesis studies concerning ginsenosides were retrospected.Additionally,the current challenges and future trends with respect to ginseng research were discussed.

    Effects of steaming process on rare saponins and efficacy of Panax ginseng,Panax notoginseng and Panax quinquefolium

    Wenjie ZhaoLinlin HanTao LiJungjoon Lee...
    521-528页
    查看更多>>摘要:The steamed Panax ginseng C.A.Mey.,Panax notoginseng(Burk.)F.H.Chen,and Panax quinquefolium L.not only facilitate storage,but also increase the content of rare saponins and enhance their clinical applica-tion value.The traditional steaming process has high energy consumption,low efficiency,and lacks stan-dardized operating procedures and unified standards.This paper retrieves the research literature on the steaming process parameters,rare saponin increments,and efficacy enhancement results of ginseng plants.By summarizing the effects of different steaming processes on rare saponins and pharmacody-namics in P.ginseng,P.notoginseng and P.quinquefolium,we explored new steaming methods and estab-lished a new quality evaluation system to provide guarantee for the effectiveness and safety of clinical medication and provide scientific basis for its rational use.

    Research progress on chemical diversity of saponins in Panax ginseng

    Xiaoyu GengJia WangYuwei LiuLinxuan Liu...
    529-547页
    查看更多>>摘要:Saponins,the major bioactive components of Panax ginseng C.A.Mey.,are gradually emerging as research hotspots owing to the possession of various pharmacological activities.This review updates the ginseno-sides list from P.ginseng and the steam-processed ginseng(red ginseng and black ginseng)up to 271 by June of 2024,encompassing 243 saponins from different parts of P.ginseng(roots,stems,leaves,flowers,berries,and seeds),103 from red ginseng,and 65 from black ginseng,respectively.Among 271 saponins,there are a total of 249(1-249)dammarane type(with a-z subtypes)tetracyclic triterpene saponins reported from each part of P.ginseng and steam-processed ginseng,two(250-251)lanostane type tetra-cyclic triterpene saponins identified from red ginseng,18(252-269)oleanane type pentacyclic triter-penoid saponins discovered from each part of P.ginseng and steam-processed ginseng,and two(270-271)ursane type pentacyclic triterpenoid saponins reported from red ginseng.Overall,this review expounds on the chemical diversity of ginsenosides in various aspects,such as chemical structure,spatial distribution and subtype comparison,processed products,and transformation.This facilitates more in-depth research on ginsenosides and contributes to the future development of ginseng.

    Mechanism of action of protopanaxadiol ginsenosides on hepatocellular carcinoma and network pharmacological analysis

    Yue ZhouZi WangShen RenWei Li...
    548-557页
    查看更多>>摘要:Hepatocellular carcinoma(HCC)is one of the most prevalent malignancies globally,posing a major chal-lenge to global health care.Protopanaxadiol ginsenosides(PDs)have been believed to significantly improve liver diseases.PDs,such as Rg3,have been developed as a new class of anti-cancer drugs.Ginsenosides Rb1,Rd,Rg3,and Rh2 exhibit effective anti-inflammatory and anti-tumor activities.Studies have confirmed that PDs could be used to treat HCC.However,the mechanism of action of PDs on HCC remains unclear.In the study,we reviewed the anti-HCC effects and mechanisms of PDs including Rb1,Rd,Rg3,Rgs,Rh2,Rk1,and Compound K(CK).Then,we searched for relevant targets of PDs and HCC from databases and enriched them for analysis.Subsequently,molecular docking was simulated to reveal molecular mechanisms.We found that PDs may treat HCC through multiple signaling pathways and related targets.PDs could inhibit the proliferation,invasion,and metastasis of HCC while promoting apoptosis and inducing differentiation.In conclusion,this review and network pharmacological analysis might offer a direction for in-depth research on related mechanisms.These insights will aid in the direc-tion of further pharmacological studies and the development of safe and effective clinical drugs.

    Network pharmacology for traditional Chinese medicine in era of artificial intelligence

    Weibo ZhaoBoyang WangShao Li
    558-560页
    查看更多>>摘要:Traditional Chinese Medicine Network Pharmacology(TCM-NP)is an interdisciplinary discipline that integrates information science,systems biology,network science and pharmacology,providing a systematic research methodology for TCM studies.With the development of artificial intelligence(Al)and multi-omics technologies,TCM-NP has entered a new era and can incorporate multimodal and high-dimensional data in the context of big data to enhance both theoretical foundations and technical capabilities.Despite its advancement,TCM-NP still faces challenges,particularly in ensuring the quality of data and research,as well as achieving more profound scientific discoveries.The field needs further innovation to obtain more precise and biomedically meaningful results.Overall research progress in TCM-NP depends on developing more accurate algorithms together with utilizing higher-quality and larger-scale data.This paper gives a perspective on the trends and characteristics of TCM-NP develop-ment and application in the era of Al.

    Treatment of constipation with Aloe and its compatibility prescriptions

    Xianhui ShenLiping GongRongrong LiNana Huang...
    561-571页
    查看更多>>摘要:Constipation is a common and prevalent digestive system disease in clinical practice,which seriously affects human physical and mental health.Currently,chemical drugs have good short-term therapeutic effects.However,because of their adverse reactions,easy recurrence after drug discontinuation,and dependence with long-term use,the long-term efficacy is unsatisfactory.The pathogenesis of constipa-tion is mainly attributed to dysfunction of zang-fu organs and imbalance of qi-blood and yin-yang,with the syndrome being asthenia in origin and asthenia in superficiality.Aloe is a traditional Chinese medi-cine with cold properties and a bitter taste,and one of the most commonly used herbs for constipation.Based on Aloe and its monomer components,combined with the existing compatibility studies of Aloe and several Chinese patent drugs represented by Aloe,this paper comprehensively and systematically intro-duced the research progress of Aloe and its compatibility prescriptions in the treatment of constipation from basic experiments to clinical observations,providing theoretical basis and medication guidance for the clinical rational application of Aloe and its prescriptions in the treatment of constipation.At the same time,it also provides the direction for future research on the mechanism of Aloe in the treatment of constipation.

    Exploration of compatibility rules and discovery of active ingredients in TCM formulas by network pharmacology

    Yishu LiuXue LiChao ChenNan Ding...
    572-588页
    查看更多>>摘要:Network pharmacology is an interdisciplinary field that utilizes computer science,technology,and bio-logical networks to investigate the intricate interplay among compounds/ingredients,targets,and dis-eases.Within the realm of traditional Chinese medicine(TCM),network pharmacology serves as a scientific approach to elucidate the compatibility relationships and underlying mechanisms of action in TCM formulas.It facilitates the identification of potential active ingredients within these formulas,pro-viding a comprehensive understanding of their holistic and systematic nature,which aligns with the holistic principles inherent in TCM theory.TCM formulas exhibit complexity due to their multi-component characteristic,involving diverse targets and pathways.Consequently,investigating their material basis and mechanisms becomes challenging.Network pharmacology has emerged as a valuable approach in TCM formula research,leveraging its holistic and systematic advantages.The manuscript aims to provide an overview of the application of network pharmacology in studying TCM formula com-patibility rules and explore future research directions.Specifically,we focus on how network pharmacol-ogy aids in interpreting TCM pharmacological theories and understanding formula compositions.Additionally,we elucidate the process of utilizing network pharmacology to identify active ingredients within TCM formulas.These findings not only offer novel research models and perspectives for integrat-ing network pharmacology with TCM theory but also present new methodologies for investigating TCM formula compatibility.All in all,network pharmacology has become an indispensable and crucial tool in advancing TCM formula research.

    Phylogenetic and spatial patterns of herbal medicine compounds:Which medicinal plants are phytochemically characterized?

    Dacheng HaoYaoxuan WangPeigen XiaoXiaojie Gu...
    589-598页
    查看更多>>摘要:Objective:The study of phytometabolites of medicinal plants and their phylogenetic distribution is an important content of pharmacophylogeny.The objectives of this study were to provide an updated esti-mate of the extent to which the medicinal plants were investigated phytochemically and relate this to the species-level phylogeny and their geographical pattern.Methods:Here,we further characterized 1 648 phytometabolites,including terpenoids,steroids,flavo-noids,phenylpropanoids,phenolics,alkaloids,etc.,reported in journals Chinese Traditional and Herbal Drugs(Zhong Cao Yao)and Chinese Herbal Medicines(CHM)from the phylogenetic and spatial perspec-tives.According to the structural characteristics,terpenoids,flavonoids,alkaloids and phenylpropanoids were subdivided into subclasses,and the research effort of phytometabolites was for the first time delin-eated at both subclass and phylogenetic levels.Results:The phytometabolites of 90 families were reported on two journals in three years.It is noted that terpenoids with diverse bioactivities still constitute the primary object of phytochemical research,fol-lowed by flavonoids,phenolics,phenylpropanoids and alkaloids.Among the reported species,the family Asteraceae had the most,followed by Lamiaceae,Fabaceae,and Ranunculaceae.In the phylogenetic dis-tribution of the reported phytometabolites,the net relatedness index(NRI)results revealed a clustered structure for triterpene,iridoid,flavone,flavonol,coumarin,indole alkaloid and terpenoid alkaloid,while the nearest taxon index(NTI)metric identified the clustered structure for triterpene,sesquiterpene,indole alkaloid and terpenoid alkaloid.Especially in Ranunculaceae,there were more reports on triter-pene and terpenoid alkaloid subclasses.The overdispersion pattern of diterpene and phenolic was sug-gested by NRI and NTI respectively,albeit more reported diterpenes and phenolics were in Lamiaceae.The geographical distribution hotspots of reported species and compounds thereof highlighted the enor-mous progress of herbal medicine research and industry,which play a positive role in the future drug dis-covery and development.Conclusion:These results provide new dimensions and perspectives in the context of pharmacophy-logeny for perceiving and evaluating research trends and flashpoints in medicinal phytochemistry.