首页|A six-herb Chinese medicine composition ointment as a promising candidate for treatment of hypertrophic scars

A six-herb Chinese medicine composition ointment as a promising candidate for treatment of hypertrophic scars

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Objective:To study the anti-hypertrophic scar effect of the six-herb Chinese medicine composition(SCMC) ointment on the rabbit ear hypertrophic scar models.Methods:The optimal formulation of SCMC ointment matrix was screened by the orthogonal designs and a series of evaluation tests.The SCMC ointment was prepared through emulsifying method.The rabbit ear hypertrophic scar models were established and used to investigate the anti-hypertrophic scar effect of SCMC ointment.Results:Our results demonstrated that all the quality control indications of the SCMC ointment met the requirements.Anti-hypertrophic scar activity results showed that all the rabbit ear scar tissues appeared different degrees of shrink and fading,and took an unobvious but palpable shift from hard to soft texture with the low,middle and high concentration SCMC ointments treatments in vivo.Additionally,on 21st day the scar area and thickness in different concentrations of SCMC ointment groups were significantly reduced than control group,in a concentration-dependent manner.The immunohistochemical results also indicated that the SCMC ointment had good anti-hypertrophic scar properties and could inhibit hypertrophic scar formation.Conclusion:The SCMC ointment could improve the blood circulation condition of hypertrophic scar tis-sues.Our research has demonstrated the Chinese medicine composition ointment with good anti-hypertrophic scar properties that could be used to treat hypertrophic scars.Meanwhile,it provides a the-oretical basis for further clinical application.

anti-hypertrophic scar effectChinese medicinehypertrophic scarsointmentorthogonal design

Zu-hua Wang、Xue-yan Sun、Jiao-jiao Zhang、Francesca Giampieri、Cheng-ju Jiang、Ting-ting Feng、Zhi-wei Wang、Rong-yi Chen、Maurizio Battino、Ying Zhou

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College of Pharmaceutical Sciences,Guizhou University of Traditional Chinese Medicine,Guiyang 550025,China

Nano-drug Technology Research Center of Guizhou University of Traditional Chinese Medicine,Guiyang 550025,China

Department of Clinical Sciences,Faculty of Medicine,Università Politecnica delle Marche,Ancona 60131,Italy

School of Medicine,Southern Medical University,Guangzhou 510091,China

Department of Biochemistry,Faculty of Sciences,King Abdulaziz University,Jeddah 21589,Saudi Arabia

QianDongNan Vocational & Technical College for Nationalities,Kaili 556000,China

International Research Center for Food Nutrition and Safety,Jiangsu University,Zhenjiang 212013,China

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research was supported by grants from Academic Talent Project of Guizhou Provincial Department of Science and Technol-ogyDoctorial Start-up Foundation of Guizhou University of Traditional Chinese Medi-cineGuizhou discipline construction projectNational Key Research and Develop-ment Program of ChinaUniversity Students Chinese Medicine Preparation Innovation and Entrepreneurship StudioProgram for University Students Innovation and Entrepreneurship Plan of Guizhou University of Traditional Chinese MedicineGuiz-hou Province Top Major Chinese MedicineGuizhou High-Level Innovative Talents Training Program

Qiankehe Platform Talent20175735-282016-3043-043160011GNYL20170082018YFC1708100Qiangaojiaofa2017158GZY Dachuanghe 2018 30Qianjiaogaofa2017158Qiankehe20154032

2021

中草药(英文版)
天津药物研究院 中国医学科学院药用植物研究所

中草药(英文版)

CSTPCD
影响因子：0.6
ISSN：1674-6384
年,卷(期)：2021.13(2)
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