中草药(英文版)2024，Vol.16Issue(1) ：13-26.DOI:10.1016/j.chmed.2023.01.007

Strategies on biosynthesis and production of bioactive compounds in medicinal plants

Miaoxian Guo Haizhou Lv Hongyu Chen Shuting Dong Jianhong Zhang Wanjing Liu Liu He Yimian Ma Hua Yu Shilin Chen Hongmei Luo
中草药(英文版)2024，Vol.16Issue(1) ：13-26.DOI:10.1016/j.chmed.2023.01.007
✕
  • NETL
  • NSTL
  • 万方数据

Strategies on biosynthesis and production of bioactive compounds in medicinal plants

Miaoxian Guo 1Haizhou Lv 1Hongyu Chen 1Shuting Dong 1Jianhong Zhang 1Wanjing Liu 1Liu He 2Yimian Ma 2Hua Yu 3Shilin Chen 4Hongmei Luo2
扫码查看

作者信息

  • 1. Key Lab of Chinese Medicine Resources Conservation,State Administration of Traditional Chinese Medicine of China,Institute of Medicinal Plant Development,Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing 100193,China
  • 2. Key Lab of Chinese Medicine Resources Conservation,State Administration of Traditional Chinese Medicine of China,Institute of Medicinal Plant Development,Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing 100193,China;Engineering Research Center of Chinese Medicine Resource,Ministry of Education,Beijing 100193,China
  • 3. Key Laboratory of Hangzhou City for Ecosystem Protection and Restoration,College of Life and Environmental Sciences,Hangzhou Normal University,Hangzhou 311121,China
  • 4. Chengdu University of Traditional Chinese Medicine,Chengdu 611137,China
  • 折叠

Abstract

Medicinal plants are a valuable source of essential medicines and herbal products for healthcare and dis-ease therapy.Compared with chemical synthesis and extraction,the biosynthesis of natural products is a very promising alternative for the successful conservation of medicinal plants,and its rapid development will greatly facilitate the conservation and sustainable utilization of medicinal plants.Here,we summa-rize the advances in strategies and methods concerning the biosynthesis and production of natural prod-ucts of medicinal plants.The strategies and methods mainly include genetic engineering,plant cell culture engineering,metabolic engineering,and synthetic biology based on multiple"OMICS"technolo-gies,with paradigms for the biosynthesis of terpenoids and alkaloids.We also highlight the biosynthetic approaches and discuss progress in the production of some valuable natural products,exemplifying com-pounds such as vindoline(alkaloid),artemisinin and paclitaxel(terpenoids),to illustrate the power of biotechnology in medicinal plants.

Key words

biosynthetic strategies/biotechnology/natural products/medicinal plants/synthetic biology

引用本文复制引用

基金项目

National Natural Science Foundation of China(81973422)

Chinese Academy of Medical Sciences(CAMS)Innovation Fund for Medical Sciences(CIFMS)

Chinese Academy of Medical Sciences(CAMS)Innovation Fund for Medical Sciences(2021-12M-1-071)

出版年

2024
中草药(英文版)
天津药物研究院 中国医学科学院药用植物研究所

中草药(英文版)

CSTPCD
影响因子：0.6
ISSN：1674-6384
参考文献量137
段落导航相关论文