首页|Strategies on biosynthesis and production of bioactive compounds in medicinal plants
Strategies on biosynthesis and production of bioactive compounds in medicinal plants
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Medicinal plants are a valuable source of essential medicines and herbal products for healthcare and dis-ease therapy.Compared with chemical synthesis and extraction,the biosynthesis of natural products is a very promising alternative for the successful conservation of medicinal plants,and its rapid development will greatly facilitate the conservation and sustainable utilization of medicinal plants.Here,we summa-rize the advances in strategies and methods concerning the biosynthesis and production of natural prod-ucts of medicinal plants.The strategies and methods mainly include genetic engineering,plant cell culture engineering,metabolic engineering,and synthetic biology based on multiple"OMICS"technolo-gies,with paradigms for the biosynthesis of terpenoids and alkaloids.We also highlight the biosynthetic approaches and discuss progress in the production of some valuable natural products,exemplifying com-pounds such as vindoline(alkaloid),artemisinin and paclitaxel(terpenoids),to illustrate the power of biotechnology in medicinal plants.
Key Lab of Chinese Medicine Resources Conservation,State Administration of Traditional Chinese Medicine of China,Institute of Medicinal Plant Development,Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing 100193,China
Engineering Research Center of Chinese Medicine Resource,Ministry of Education,Beijing 100193,China
Key Laboratory of Hangzhou City for Ecosystem Protection and Restoration,College of Life and Environmental Sciences,Hangzhou Normal University,Hangzhou 311121,China
Chengdu University of Traditional Chinese Medicine,Chengdu 611137,China
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National Natural Science Foundation of ChinaChinese Academy of Medical Sciences(CAMS)Innovation Fund for Medical SciencesChinese Academy of Medical Sciences(CAMS)Innovation Fund for Medical Sciences
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