Abstract
Traditional Chinese medicines(TCMs)possess a rich historical background,unique theoretical frame-work,remarkable therapeutic efficacy,and abundant resources.However,the modernization and inter-nationalization of TCMs have faced significant obstacles due to their diverse ingredients and unknown mechanisms.To gain deeper insights into the phytochemicals and ensure the quality control of TCMs,there is an urgent need to enhance analytical techniques.Currently,two-dimensional(2D)chromatogra-phy,which incorporates two independent separation mechanisms,demonstrates superior separation capabilities compared to the traditional one-dimensional(1D)separation system when analyzing TCMs samples.Over the past decade,new techniques have been continuously developed to gain action-able insights from complex samples.This review presents the recent advancements in the application of multidimensional chromatography for the quality evaluation of TCMs,encompassing 2D-gas chromatog-raphy(GC),2D-liquid chromatography(LC),as well as emerging three-dimensional(3D)-GC,3D-LC,and their associated data-processing approaches.These studies highlight the promising potential of multidi-mensional chromatographic separation for future phytochemical analysis.Nevertheless,the increased separation capability has resulted in higher-order data sets and greater demands for data-processing tools.Considering that multidimensional chromatography is still a relatively nascent research field,fur-ther hardware enhancements and the implementation of chemometric methods are necessary to foster its robust development.
基金项目
Hunan 2011 Collaborative Innovation Center of Chemical Engineering & Technology with Environmental Benignity and Effective R()
Hunan Province Natural Science Fund(2020JJ4569)
Hunan Province Natural Science Fund(2023JJ60378)
Hunan Province College Students'Innovation and Entrepreneurship Training Program(S202110530044)
Hunan Province College Students'Innovation and Entrepreneurship Training Program(S202210530048)
NETL
NSTL
万方数据