首页|Gain deeper insights into traditional Chinese medicines using multidimensional chromatography combined with chemometric approaches

Gain deeper insights into traditional Chinese medicines using multidimensional chromatography combined with chemometric approaches

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Traditional Chinese medicines(TCMs)possess a rich historical background,unique theoretical frame-work,remarkable therapeutic efficacy,and abundant resources.However,the modernization and inter-nationalization of TCMs have faced significant obstacles due to their diverse ingredients and unknown mechanisms.To gain deeper insights into the phytochemicals and ensure the quality control of TCMs,there is an urgent need to enhance analytical techniques.Currently,two-dimensional(2D)chromatogra-phy,which incorporates two independent separation mechanisms,demonstrates superior separation capabilities compared to the traditional one-dimensional(1D)separation system when analyzing TCMs samples.Over the past decade,new techniques have been continuously developed to gain action-able insights from complex samples.This review presents the recent advancements in the application of multidimensional chromatography for the quality evaluation of TCMs,encompassing 2D-gas chromatog-raphy(GC),2D-liquid chromatography(LC),as well as emerging three-dimensional(3D)-GC,3D-LC,and their associated data-processing approaches.These studies highlight the promising potential of multidi-mensional chromatographic separation for future phytochemical analysis.Nevertheless,the increased separation capability has resulted in higher-order data sets and greater demands for data-processing tools.Considering that multidimensional chromatography is still a relatively nascent research field,fur-ther hardware enhancements and the implementation of chemometric methods are necessary to foster its robust development.

chemometricsmultidimensional separationoff-line two-dimensional liquidchromatographyon-line two-dimensional liquidchromatographyquality controltraditional chinese medicinestwo-dimensional gas chromatography

Xinyue Yang、Pingping Zeng、Jin Wen、Chuanlin Wang、Liangyuan Yao、Min He

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Department of Pharmaceutical Engineering,School of Chemical Engineering,Xiangtan University,Xiangtan 411105,China

Hunan Qianjin Xiangjiang Pharmaceutical Joint Stock Co.,Ltd.,Zhuzhou 412000,China

Hunan 2011 Collaborative Innovation Center of Chemical Engineering & Technology with Environmental Benignity and Effective RHunan Province Natural Science FundHunan Province Natural Science FundHunan Province College Students'Innovation and Entrepreneurship Training ProgramHunan Province College Students'Innovation and Entrepreneurship Training Program

2020JJ45692023JJ60378S202110530044S202210530048

2024

10.1016/j.chmed.2023.07.001

中草药(英文版)
天津药物研究院 中国医学科学院药用植物研究所

中草药(英文版)

CSTPCD
影响因子：0.6
ISSN：1674-6384
年,卷(期)：2024.16(1)
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