首页|Hypoxia inducible factor-1α related mechanism and TCM intervention in process of early fracture healing

Hypoxia inducible factor-1α related mechanism and TCM intervention in process of early fracture healing

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As a common clinical disease,fracture is often accompanied by pain,swelling,bleeding as well as other symptoms and has a high disability rate,even threatening life,seriously endangering patients'physical and psychological health and quality of life.Medical practitioners take many strategies for the treatment of fracture healing,including Traditional Chinese Medicine(TCM).In the early stage of fracture healing,the local fracture is often in a state of hypoxia,accompanied by the expression of hypoxia inducible factor-1α(HIF-1α),which is beneficial to wound healing.Through literature mining,we thought that hypoxia,HIF-1α and downstream factors affected the mechanism of fracture healing,as well as domi-nated this process.Therefore,we reviewed the local characteristics and related signaling pathways involved in the fracture healing process and summarized the intervention of TCM on these mechanisms,in order to inspirit the new strategy for fracture healing,as well as elaborate on the possible principles of TCM in treating fractures based on the HIF molecular mechanism.

fracture healinghypoxiahypoxia inducible factor-1αtraditional chinese medicinemolecular mechanism

Wenxian Zhang、Fusen Yang、Qikai Yan、Jiahui Li、Xiaogang Zhang、Yiwei Jiang、Jianye Dai

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Affiliated Hospital of Gansu University of Traditional Chinese Medicine,Lanzhou 730000,China

School of Pharmacy,Lanzhou University,Lanzhou 730000,China

Xi'an Hospital of Traditional Chinese Medicine,Xi'an 710021,China

National Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaScience and Technology Planning Project of Tibet Autonomous RegionFundamental Research Funds for the Central Universities

8206087782104527XZ202101ZD 0022Glzujbky-2022-ct03

2024

10.1016/j.chmed.2023.09.006

中草药(英文版)
天津药物研究院 中国医学科学院药用植物研究所

中草药(英文版)

CSTPCD
影响因子：0.6
ISSN：1674-6384
年,卷(期)：2024.16(1)
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