首页|Chemical components in cultivated Cordyceps sinensis and their effects on fibrosis

Chemical components in cultivated Cordyceps sinensis and their effects on fibrosis

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Objective:Cultivated Cordyceps sinensis powder has been used as clinical drug and healthy food to nour-ish the lung and kidney,which solves the problem of serious shortage of wild C.sinensis.This study aims to explore the chemical components and compared their anti-fibrotic effects in cultivated C.sinensis.Methods:Nucleosides,sterols and polysaccharides were separated and purified from cultivated C.sinen-sis,and analyzed by high performance liquid chromatography,gas chromatography-mass spectrometry and chemical chromogenic methods,respectively.In high glucose-induced rat mesangial cell models,fibronectin and type 1 collagen were used as evaluation indicators.Results:There were 10 kinds of nucleosides and one sterol in cultivated C.sinensis.The contents of nucle-osides,sterols and polysaccharides in the cultivated C.sinensis were close to 2％,0.55％and 4.4％,respec-tively.Furthermore,nucleoside,sterol and polysaccharide components exhibited varying degrees of anti-fibrotic activity.The nucleoside components and sterol components inhibited the expression of extracel-lular matrix more effectively in the three main components.Conclusion:Cultivated C.sinensis remains the similar compounds with the wild C.sinensis,and nucleo-sides and sterols may be the main active substances that contribute to its anti-fibrotic effects.The project of this study may provide valuable information on further optimization of more effective remedies with few side effects based on cultivated C.sinensis.

anti-fibrotic effectscultivated Cordyceps sinensisergosterolnucleosidespolysaccharides

Zhonghua Dong、Xiao Sun

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Department of Clinical Pharmacy,The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital,Shandong Engineering and Technology Research Center for Pediatric Drug Development,Shandong Medicine and Health Key Laboratory of Clinical Pharmacy,Jinan 250014,China

Department of Emergency Medicine,Qilu Hospital of Shandong University,Jinan 250012,China

Shandong Provincial Clinical Research Center for Emergency and Critical Care Medicine,Institute of Emergency and Critical Care Medicine of Shandong University,Chest Pain Center,Qilu Hospital of Shandong University,Jinan 250012,China

Key Laboratory of Emergency and Critical Care Medicine of Shandong Province,Key Laboratory of Cardiopulmonary-Cerebral Resuscitation Research of Shandong Province,Shandong Provincial Enginee

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Shandong Provincial Natural Science Foundation

ZR2021QH296

2024

10.1016/j.chmed.2022.11.008

中草药(英文版)
天津药物研究院 中国医学科学院药用植物研究所

中草药(英文版)

CSTPCD
影响因子：0.6
ISSN：1674-6384
年,卷(期)：2024.16(1)
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