首页|New indole derivatives from endophytic fungus Colletotruchum sp.HK-08 originated from leaves of Nerium indicum
New indole derivatives from endophytic fungus Colletotruchum sp.HK-08 originated from leaves of Nerium indicum
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Objective:To study secondary metabolites from endophytic fungus Colletotruchum sp.HK-08 originated from the leaves of Nerium indicum.Methods:The compounds were isolated by various column chromatographic techniques,and their struc-tures were elucidated by spectroscopic techniques[high resolution electrospray ionization mass spec-troscopy(HRESIMS),one-dimensional(1D)and two-dimensional(2D)nuclear magnetic resonance spectroscopy(NMR)],as well as comparison with literature data.The Ellman method was used to deter-mine the acetylcholinesterase(AChE)inhibitory activity.Results:Four indole derivatives were identified from Colletotruchum sp.HK-08,including 6'-hydroxy-monaspiloindole(1),2-(2-oxoindolin-3-yl)ethyl 2-(4-hydroxyphenyl)acetate(2),2-(2-oxoindolin-3-yl)ethyl 2-(2-hydroxyphenyl)acetate(3),and monaspiloindole(4).Compound 4 presented weak AChE inhi-bitory activity with IC50 value of(69.30±6.27)μmol/L[tacrine as the positive control,with IC50 value of(0.61±0.07)μmol/L].Conclusion:Compounds 1-3 were new compounds,and compound 4 had weak AChE inhibitory activity.
Huiqin Chen、Hao Zheng、Caihong Cai、Hao Wang、Cuijuan Gai、Zhiqiong Tan、Haofu Dai、Wenli Mei
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Hainan Key Laboratory of Research and Development of Natural Product from Li Folk Medicine,Institute of Tropical Bioscience and Biotechnology,Chinese Academy of Tropical Agricultural Sciences,Haikou 571101,China
Hainan Institute for Tropical Agricultural Resources,Haikou 571101,China
School of Life and Pharmaceutical Sciences,Hainan University,Haikou 570228,China
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