首页|Shouhui Tongbian Capsule in treatment of constipation:Treatment and mechanism development

Shouhui Tongbian Capsule in treatment of constipation:Treatment and mechanism development

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Constipation is common in the diseases of the digestive system in clinics.With the change in diet struc-ture and the increase in life pressure,the prevalence rate increases year by year.In traditional Chinese medicine(TCM),the location of the disease of constipation is in the large intestine,which is related to the dysfunction of lung,spleen,liver,kidney and other viscera.Its pathogenesis is conductive dysfunction of large intestine.Based on the theory,Shouhui Tongbian Capsule(SHTB)is composed of eight traditional Chinese medicines,including Polygoni multiflori Radix(Heshouwu in Chinese),Aloe(Luhui in Chinese),Cassiae Semen(Juemingzi in Chinese),Ginseng Radix et Rhizoma(Renshen in Chinese),Lycii Fructus(Gouqizi in Chinese),Asini Corii Colla(Ejiao in Chinese),Aurantii Fructus Immaturus(Zhishi in Chinese),and Atractylodis Macrocephalae Rhizoma(Baizhu in Chinese),which could help to release excessive turbid,and nourishing yin and supplementing qi in the treatment.This study has been carried out to review the latest advances of SHTB in the treatment of constipation.The results showed that significant effect of SHTB was found in the treatment of constipation,such as functional constipation,and constipation asso-ciated with tumor chemotherapy,colitis,type 2 diabetes and chronic cardiac failure.Besides,obvious adverse reactions were not observed.SHTB could effectively treat five types of constipation,provide direction for the future exploration of SHTB in the treatment of other types of constipation.

constipationgastrointestinal hormonesinterstitial cells of cajalintestinal fluid secretionintestinal motilityShouhui Tongbian Capsule

Liping Gong、Hang Du、Xin Guo、Jianchao Li、Xiaomin Zhu、Xianhui Shen、Zhiyan Huang、Kaiyi Wu、Guimin Zhang、Rong Sun

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The Second Hospital of Shandong University,Jinan 250033,China

State Key Laboratory of Generic Manufacture Technology of Chinese Traditional Medicine,Lunan Pharmaceutical Group Co.,Ltd.,Linyi 276006,China

Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China

Shandong University of Traditional Chinese Medicine,Jinan 250355,China

Advanced Medical Research Institute,Shandong University,Jinan 250012,China

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国家重点研发计划Cutting Edge Development Fund of Advanced Medical Research Institute,Lunan Hope Pharmaceutical Co.,LtdScientific and Technological Innovation Program for Clinical Medicine of JinanCultivation Fund Program of the Second Hospital of Shandong University

2022YFC350210015200190132020191322022YP14

2024

10.1016/j.chmed.2023.05.006

中草药(英文版)
天津药物研究院 中国医学科学院药用植物研究所

中草药(英文版)

CSTPCD
影响因子：0.6
ISSN：1674-6384
年,卷(期)：2024.16(2)
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