首页|Constituents from leaves of Macaranga hemsleyana
Constituents from leaves of Macaranga hemsleyana
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Objective:To study constituents of the leaves of Macaranga hemsleyana,and evaluate their inhibitory effects against NOD-like receptor thermal protein domain associated protein 3(NLRP3)inflammasome activation,and antiproliferative activity.Methods:The constituents were isolated and purified by column chromatography on MCI gel CHP20P/P120,silica gel,Sephadex LH-20,and HPLC.The structures of compounds were determined by 1D,2D NMR,and HR-ESI-MS data.The inhibitory effect of compounds on inflammasome activation was deter-mined by lactate dehydrogenase(LDH)procedure.The antiproliferative activity was evaluated using MTT assay.Results:The study led to the isolation of 23 compounds,including one new compound,identified as(2Z)-3-[4-(β-D-glucopyranosyloxy)-2'-hydroxy-5'-methoxyphenyl]-2-propenoic acid(1),together with 22 known compounds recognized as 1,4-dihydro-4-oxo-3-pyridinecarbonitrile(2),methyl 4-methoxynicotinate(3),4-methoxynicotinonitrile(4),1-(3-O-β-D-glucopyranosyl-4,5-dihydroxyphenyl)-ethanone(5),neoisoastilbin(6),isoastilbin(7),aromadendrin(8),neoastilbin(9),astilbin(10),quercitrin(11),neoschaftoside(12),apigenin 6,8-bis-C-α-L-arabinoside(13),vitexin(14),bergenin(15),scopoletin(16),glucopyranoside salicyl(17),koaburside(18),benzyl β-D-glucoside(19),icariside B5(20),roseoside(21),loliolide(22),and adenosine(23).The tested compounds did not show LDH inhibition nor antipro-liferative activity.Conclusion:Compound 1 was a new glycoside.Compounds 2 and 3 were obtained for the first time from natural source.The 22 known compounds constituted of alkaloids(2-4,23),phenolics(5,15,17,18),fla-vonoids(6-14),coumarin(16),benzyl glycoside(19),and norsesquiterpenes(20-22).All the compounds,1-23,were revealed from M.hemsleyana for the first time.This is the initial uncovering of molecules 1-10,12,13,17-19,and 23 from the genus Macaranga.The isolated compounds,11,14-16,and 20-22 established taxonomic classification of M.hemsleyana in Euphorbiaceae family.Flavonoids were out-standing as chemosystematic markers of Macaranga genus.
antiproliferative activitychemotaxonomic significanceflavonoidsglycosideMacaranga hemsleyana Pax et HoffmNLRP3 inflammasome
Joseph Sakah Kaunda、Jia Liu、Yaojun Xu、Yuansi Chen、Chenfang Yue、Xingjie Zhang、Ruihan Zhang、Muhammad Amin、Weilie Xiao、Hongliang Li、Xiaoli Li
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Key Laboratory of Medicinal Chemistry for Natural Resource,Ministry of Education,Yunnan Characteristic Plant Extraction Laboratory,Yunnan Provincial Center for Research& Development of Natural Products,State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan,School of Pharmacy,School of Medicine,Chemical Science and Technology,Yunnan University,Kunming 650500,China
Yunnan Key Laboratory of Pharmacology for Natural Products,Haiyuan College,Kunming Medical University,Kunming 650500,China
National Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaProject of Yunnan Characteristic Plant Screening and R&D Service CXO Platform
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