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Research progress on chemical diversity of saponins in Panax ginseng

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Research progress on chemical diversity of saponins in Panax ginseng
Saponins,the major bioactive components of Panax ginseng C.A.Mey.,are gradually emerging as research hotspots owing to the possession of various pharmacological activities.This review updates the ginseno-sides list from P.ginseng and the steam-processed ginseng(red ginseng and black ginseng)up to 271 by June of 2024,encompassing 243 saponins from different parts of P.ginseng(roots,stems,leaves,flowers,berries,and seeds),103 from red ginseng,and 65 from black ginseng,respectively.Among 271 saponins,there are a total of 249(1-249)dammarane type(with a-z subtypes)tetracyclic triterpene saponins reported from each part of P.ginseng and steam-processed ginseng,two(250-251)lanostane type tetra-cyclic triterpene saponins identified from red ginseng,18(252-269)oleanane type pentacyclic triter-penoid saponins discovered from each part of P.ginseng and steam-processed ginseng,and two(270-271)ursane type pentacyclic triterpenoid saponins reported from red ginseng.Overall,this review expounds on the chemical diversity of ginsenosides in various aspects,such as chemical structure,spatial distribution and subtype comparison,processed products,and transformation.This facilitates more in-depth research on ginsenosides and contributes to the future development of ginseng.

chemical diversityPanax ginseng C.A.Mey.pentacyclic triterpenoidssaponinstetracyclic triterpenoids

Xiaoyu Geng、Jia Wang、Yuwei Liu、Linxuan Liu、Xuekun Liu、Yan Zhao、Cuizhu Wang、Jinping Liu

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School of Pharmaceutical Sciences,Jilin University,Changchun 130021,China

School of Pharmacy and Medicine,Tonghua Normal University,Tonghua 134002,China

College of Chinese Medicinal Materials,Jilin Agricultural University,Changchun 130118,China

chemical diversity Panax ginseng C.A.Mey. pentacyclic triterpenoids saponins tetracyclic triterpenoids

2024

中草药(英文版)
天津药物研究院 中国医学科学院药用植物研究所

中草药(英文版)

CSTPCD
影响因子:0.6
ISSN:1674-6384
年,卷(期):2024.16(4)