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Mechanism of action of protopanaxadiol ginsenosides on hepatocellular carcinoma and network pharmacological analysis

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Mechanism of action of protopanaxadiol ginsenosides on hepatocellular carcinoma and network pharmacological analysis
Hepatocellular carcinoma(HCC)is one of the most prevalent malignancies globally,posing a major chal-lenge to global health care.Protopanaxadiol ginsenosides(PDs)have been believed to significantly improve liver diseases.PDs,such as Rg3,have been developed as a new class of anti-cancer drugs.Ginsenosides Rb1,Rd,Rg3,and Rh2 exhibit effective anti-inflammatory and anti-tumor activities.Studies have confirmed that PDs could be used to treat HCC.However,the mechanism of action of PDs on HCC remains unclear.In the study,we reviewed the anti-HCC effects and mechanisms of PDs including Rb1,Rd,Rg3,Rgs,Rh2,Rk1,and Compound K(CK).Then,we searched for relevant targets of PDs and HCC from databases and enriched them for analysis.Subsequently,molecular docking was simulated to reveal molecular mechanisms.We found that PDs may treat HCC through multiple signaling pathways and related targets.PDs could inhibit the proliferation,invasion,and metastasis of HCC while promoting apoptosis and inducing differentiation.In conclusion,this review and network pharmacological analysis might offer a direction for in-depth research on related mechanisms.These insights will aid in the direc-tion of further pharmacological studies and the development of safe and effective clinical drugs.

anti-hepatocellular carcinomaginsenoside Rb1ginsenoside Rdginsenoside Rg3ginsenoside Rg5ginsenoside Rh2ginsenoside Rk1network pharmacologyprotopanaxadiol ginsenosides

Yue Zhou、Zi Wang、Shen Ren、Wei Li

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College of Chinese Medicinal Materials,Jilin Agricultural University,Changchun 130118,China

College of Life Sciences,Jilin Agricultural University,Changchun 130118,China

anti-hepatocellular carcinoma ginsenoside Rb1 ginsenoside Rd ginsenoside Rg3 ginsenoside Rg5 ginsenoside Rh2 ginsenoside Rk1 network pharmacology protopanaxadiol ginsenosides

2024

10.1016/j.chmed.2024.06.002

中草药(英文版)
天津药物研究院 中国医学科学院药用植物研究所

中草药(英文版)

CSTPCD
影响因子：0.6
ISSN：1674-6384
年,卷(期)：2024.16(4)