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TPMGD:A genomic database for the traditional medicines in Pakistan

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Objective:In Pakistan,traditional medicines are an important component of the medical system,with numerous varieties and great demands.However,due to the scattered resources and the lack of system-atic collection and collation,adulteration of traditional Pakistani medicine(TPM)is common,which severely affects the safety of their medicinal use and the import and export trades.Therefore,it is urgent to systematically organize and unify the management of TPM and establish a set of standards and oper-able methods for the identification of TPM.Methods:We collected and organized the information on 128 TPMs with regard to their medicinal parts,efficacy,usage,and genetic material,based on Pakistan Hamdard Pharmacopoeia of Eastern Medicine:Pharmaceutical Codex.The genetic information of TPM is summarized from national center for biotechnol-ogy information(NCB1)and global pharmacopoeia genome database(GPGD).Furthermore,we utilized bioinformatics technology to supplement the chloroplast genome(cp-genome)data of 12 TPMs.To build the web server,we used the Linux+Apache+MySQL+PHP(LAMP)system and constructed the webpage on a PHP:Hypertext Preprocessor(PHP)model view controller(MVC)framework.Results:We constructed a new genomic database,the traditional Pakistani medicine genomic database(TPMGD).This database comprises five entries,namely homepage,medicinal species,species identifica-tion,basic local alignment search tool(BLAST),and download.Currently,TPMGD contains basic profiles of 128 TPMs and genetic information of 102 TPMs,including 140 cytochrome c oxidase subunit I(COI)sequences and 119 mitochondrial genome sequences from Bombyx mori,1 396 internal transcribed spacer 2(ITS2)sequences and 1 074 intergenic region(psbA-trnH)sequences specific to 92 and 83 plant species,respectively.Additionally,TPMGD includes 199 cp-genome sequences of 82 TPMs.Conclusion:TPMGD is a multifunctional database that integrates species description,functional informa-tion inquiry,genetic information storage,molecular identification of TPM,etc.The database not only pro-vides convenience for TPM information queries but also establishes the scientific basis for the medication safety,species identification,and resource protection of TPM.

chloroplast genomedatabaseDNA barcodesPakistantraditional medicine

Rushuang Xiang、Huihua Wan、Wei Sun、Baozhong Duan、Weiqian Chen、Xue Cao、Sifan Wang、Chi Song、Shilin Chen、Yan Wang、Atia-tul Wahab、M.Iqbal Choudhary、Xiangxiao Meng

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State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs,Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences,Beijing 100700,China

Key Laboratory of Beijing for Identification and Safety Evaluation of Chinese Medicine,Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences,Beijing 100700,China

College of Pharmaceutical Science,Dali University,Dali 671000,China

H.E.J.Research Institute of Chemistry,International Center for Chemical and Biological Sciences,University of Karachi,Karachi 75270,Pakistan

Dr.Panjwani Center for Molecular Medicine and Drug Research,International Center for Chemical and Biological Sciences,University of Karachi,Karachi 75270,Pakistan

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2025

10.1016/j.chmed.2024.03.004

中草药(英文版)
天津药物研究院 中国医学科学院药用植物研究所

中草药(英文版)

影响因子：0.6
ISSN：1674-6384
年,卷(期)：2025.17(1)