山沉香化学成分研究
Chemical constituents from Syringa pinnatifolia
曾孝杰 1王国才 1吴霞 1李国强 1叶文才 1李药兰1
作者信息
- 1. 暨南大学药学院中药及天然药物研究所,广东广州510632;暨南大学中药药效物质基础及创新药物研究广东省高校重点实验室,广东广州510632
- 折叠
摘要
目的 研究山沉香Syringa pinnatifolia干燥茎的化学成分.方法 采用硅胶、ODS、Sephadex LH-20及RP-HPLC等色谱技术对山沉香干燥茎的化学成分进行分离纯化,根据理化性质及波谱数据鉴定化合物结构.结果 从山沉香干燥茎95％乙醇提取物的醋酸乙酯部位分离得到11个化合物,分别鉴定为开环异落叶松脂醇(1)、(8R,8'R,9R)-3,3',9-三甲氧基-4,4'-二羟基-9,9'-环氧木脂素(2)、(8R,8'R,9S)-3,3',9-三甲氧基-4,4'-二羟基-9,9'-环氧木脂素(3)、左旋松脂醇(4)、(8R,8'R,9'S)-3,3',9 '-三甲氧基-4,4 '-二羟基-9,9'-环氧木脂素(5)、(8R,8'R,9'R)-3,3',9'-三甲氧基-4,4'-二羟基-9,9'-环氧木脂素(6)、(9S)-9-O-methylcubebin (7)、邻苯二甲酸二丁酯(8)、菲律宾胡椒素Ⅵ (9)、蛇菰宁(10)、落叶松萘酮(11).结论 化合物2～11均为首次从该植物中分离得到.
Abstract
Objective To investigate the chemical constituents from the stems of Syringa pinnatifolia.Methods The chemical constituents were isolated and identified by chromatography on silica gel,ODS,and Sephadex LH-20 columns,as well as RP-HPLC.Their structures were elucidated on the basis of physicochemical properties and spectral analyses.Results Eleven compounds were isolated from S.pinnatifolia and their structures were identified as secoisolariciresinol (1),(8R,8'R,9R)-4,4'-dihydroxy-3,3',9-trimethoxy-9,9'-epoxylignan (2),(8R,8'R,9S)-4,4'-dihydroxy-3,3',9-trimethoxy-9,9'-epoxylignan (3),(-)-pinoresinol (4),(8R,8'R,9'S)-4,4'-dihydroxy-3,3',9'-trimethoxy-9,9'-epoxylignan (5),(8R,8'R,9'R)-4,4'-dihydroxy-3,3',9'-trimethoxy-9,9'-epoxylignan (6),(9S)-9-O-methylcubebin (7),dibutylphthalate (8),piperphilippinin Ⅵ (9),balanophonin (10),and larixnaphthaone (11).Conclusion Compounds 2-11 are isolated from the plant for the first time.
关键词
山沉香/左旋松脂醇/(8R,8'R,9R)-3,3',9-三甲氧基-4,4'-二羟基-9,9'-环氧木脂素/邻苯二甲酸二丁酯/蛇菰宁Key words
Syringa pinnatifolia Hemsl./(-)-pinoresinol/(8R, 8'R, 9R)-4, 4'-dihydroxy-3, 3', 9-trimethoxy-9, 9'-epoxylignan/dibutylphthalate/balanophonin引用本文复制引用
基金项目
国家自然科学基金(81072535)
中央高校基本科研业务费专项资金(21612417)
出版年
2013
国家科技期刊平台
NSTL
维普
万方数据