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苗药冠盖藤的化学成分研究

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目的 研究苗药冠盖藤Pileostegia viburnoides藤茎的化学成分.方法 采用硅胶柱色谱、凝胶柱色谱及重结晶等方法进行分离纯化,利用波谱分析结合理化性质鉴定化合物的结构.结果 从苗药冠盖藤藤茎甲醇提取物中共分离得到13个化合物,分别鉴定为木栓酮(1)、3-氧代木栓烷-28-醛(2)、豆甾-4-烯-3-酮(3)、豆甾醇(4)、(24R)-5A-豆甾烷-3,6-二酮(5)、二十四烷胺(6)、乌苏酸(7)、坡模酸(8)、齐墩果酸(9)、伞形花内酯(10)、4-hydroxymellein (11)、臭矢菜素A(12)、胡萝卜苷(13).结论 化合物6为首次从天然产物中分离得到,化合物2～5、7～9、11、12均为首次从本属植物中分离得到,所有化合物均为首次从冠盖藤中分离得到.
Chemical constituents from cane of Pileostegia viburnoides
Objective To study the chemical constituents from the cane ofPileostegia viburnoides.Methods The compounds were isolated and purified by silica gel and Sephadex LH-20 column chromatography.Their structures were identified on the basis of their physicochemical properties and spectroscopic data.Results Thirteen compounds were isolated from the cane of P.viburnoides and their structures were identified as friedelin (1),3-oxo-nofriedelin-28-al (2),stigmast-4-en-3-one (3),stigmasterol (4),(24R)-5A-stigmastane-3,6-dione (5),tetracosyl amine (6),ursolic acid (7),pomolic acid (8),oleanolic acid (9),umbelliferone (10),4-hydroxymellein (11),cleomiscosin A (12),and daucosterol (13),respectively.Conclusion Compound 6 is obtained as a natural product for the first time; Compounds 2-5,7-9,11,and 12 are obtained from this genus for the first time and all the compounds are obtained from P.viburnoides for the first time.

Pileostegia viburnoides Hook.f.et Thomsstigmasteroltetracosyl amineursolic acidpomolic acidoleanolic acidcleomiscosin A

李小军、袁燕、李芝、刘向前

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湖南中医药大学药学院,湖南长沙410208

冠盖藤 豆甾醇 二十四烷胺 乌苏酸 坡模酸 齐墩果酸 臭矢菜素A

湖南省中医药科研计划项目湖南中医药大学药物分析学“十二五”校级重点学科建设项目湖南省中药学重点学科建设项目

201313620122]2013136

2014

10.7501/j.issn.0253-2670.2014.08.003

中草药
天津药物研究院,中国药学会

中草药

CSTPCDCSCD北大核心
影响因子：1.632
ISSN：0253-2670
年,卷(期)：2014.45(8)
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