微晶纤维素对五倍子提取物可压缩性和成型性的影响
Effect of microcrystalline cellulose on compressibility and moldability of Galla chinensis extract
曹韩韩 1杜若飞 1杨嘉宁 1冯怡 1赵立杰 1王松涛2
作者信息
- 1. 上海中医药大学中药现代制剂技术教育部工程研究中心,上海201203 ;上海张江中药现代制剂技术工程研究中心,上海201203
- 2. 上海中医药大学中药现代制剂技术教育部工程研究中心,上海201203 ;上海中医药大学中药学院,上海201203
- 折叠
摘要
目的 研究微晶纤维素对五倍子提取物(GCE)的可压缩性和成型性的影响.方法 选择4种型号的微晶纤维素分别以不同的比例与GCE混合均匀,使用Korsch XP-1型智能感应压片机压片,采用塑性常数、快速弹性松弛、压缩比、屈服压力、抗张强度等参数及其变化规律来评价粉体的可压缩性和成型性.结果 GCE的可压缩性和成型性非常差,4种微晶纤维素中CeolusKG802对GCE的快速弹性松弛和压缩比的改善最为明显.对于塑性常数和抗张强度:当微晶纤维素加入量较低时,AvicelDG对两者改善最为明显;当加入量较高时,CeolusKG802对两者改善最为明显.对于屈服压力:微晶纤维素的加入量较低时,CeolusKG802对屈服压力的减小优于其他3种,高加入量则相反.结论 4种微晶纤维素在压缩过程中均呈现了良好的可压缩性和成型性,但不同型号的微晶纤维素表现出不同的优势.通过研究混合粉体的压缩性,得到了不同比例和不同型号微晶纤维素对GCE的压缩参数的改变规律.
Abstract
Objective To study the effect ofmicrocrystalline cellulose (MCC) on compressibility and moldability of Galla chinensis extract (GCE).Methods Four types of MCC were chosen and mixed with GCE respectively in different proportions.The powder was tabletted by Korsch XP-1 Intelligent Induction Tablet Machine,and the compressibility and moldability were evaluated using plasticity constant,elastic recovery,compression ratio,yield pressure,tensile strength,and their change rules as indexes.Results The compressibility and moldability of GCE were poor.CeolusKG802 was the best at improving elastic recovery and compression ratio among the four kinds ofMCC.AvicelDG improved the plasticity constant and tensile strength most when the adding amount was low,and CeolusKG802 improved them most when the adding amount was high.To yield pressure,CeolusKG802 exhibited greater reduction than the other MCC when added in a low amount.As for a high amount,the result was opposite.Conclusion MCC has good compressibility and moldability in the compression process; Different types of MCC have different advantages.The change law of compression parameters is obtained by investigating the compression of mixed powders of MCC with different proportions on GCE.
关键词
微晶纤维素/五倍子提取物/直接压片/可压缩性/成型性Key words
microcrystalline cellulose/Galla chinensis extract/direct compression tableting/compressibility/moldability引用本文复制引用
基金项目
上海市科委项目(13DZ2290400)
浦东新区科技发展基金(PKF-2003-003)
出版年
2014
国家科技期刊平台
NSTL
维普
万方数据