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东北铁线莲地上部位化学成分研究

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目的 研究东北铁线莲Clematis manshurica地上部位的化学成分.方法 采用硅胶柱色谱、ODS柱色谱和制备HPLC等技术方法进行分离纯化,运用理化性质和波谱数据鉴定化合物结构.结果 从东北铁线莲地上部位乙醇提取物中分离得到17个化合物,分别鉴定为(+)-表松脂醇(1)、(+)-松脂醇(2)、(-)-表丁香树脂醇(3)、(+)-梣皮树脂醇(4)、(+)-松脂醇-4-O-β-D-吡喃葡萄糖苷(5)、(+)-丁香树脂醇-4-O-β-D-吡喃葡萄糖苷(6)、(+)-表丁香树脂醇-4-O-β-D-吡喃葡萄糖苷(7)、罗汉松脂素(8)、(+)-珍珠花环木脂素(9)、(+)-异落叶松脂素(10)、(7R,8R)-4,7,9,9'-四羟基-3,3'-二甲氧基-8-O-4'-新木脂素(11)、(7R,8S)-4,7,9,9'-四羟基-3,3'-二甲氧基-8-O-4'-新木脂素(12)、(7S,8R)-二氢脱氢双松柏醇(13)、木犀草素(14)、3''-O-(2'''-甲基丁酰基)异当药苷(15)、2''-O-(2'''-甲基丁酰基)异当药苷(16)、6''-O-(2'''-甲基丁酰基)异当药苷(17).结论 所有化合物均为首次从该植物地上部位中分离得到,其中化合物1、3、4、7～9、11、12、15～17为首次从该属植物中分离得到.
Chemical constituents from aerial parts of Clematis manshurica
Objective To investigate the chemical constituents from the ethanol extract of aerial parts of Clematis manshurica.Methods The compounds were isolated and purified by chromatography on silica gel,ODS,and preparative HPLC.Their structures were elucidated on the basis of chemical and spectroscopic methods,including MS,1D,and 2D NMR spectral techniques.Results Seventeen compounds were isolated from the ethanol extract of the aerial parts of C.manshurica,and were identified as (+)-epipinoresinol (1),(+)-pinoresinol (2),(-)-episyringaresinol (3),(+)-medioresinol (4),(+)-pinoresinol-4-O-β-D-glucopyranoside (5),(+)-syringaresinol-4-O-β-D-glucopyranoside (6),(+)-episyringaresinol-4-O-β-D-glucopyranoside (7),matairesinol (8),(+)-lyoniresinol (9),(+)-isolariciresinol (10),(7R,8R)-4,7,9,9'-tetrahydroxy-3,3'-diethoxy-8-O-4'-neolignan (11),(7R,8S)-4,7,9,9'-tetrahydroxy-3,3'-diethoxy-8-O-4'-neolignan (12),(7S,8R)-dihydrodehydroconiferyl alcohol (13),luteolin (14),3''-O-(2'''-methylbutyryl) isoswertisin (15),2"-O-(2'"-methylbutyryl) isoswertisin (16),and 6''-O-(2'''-methylbutyryl) isoswertisin (17) Conclusion All compounds are obtained from the aerial parts of this plant for the first time,and compounds 1,3,4,7-9,11,12,and 15-17 are firstly isolated from the plants of Clematis L.

RanunculaceaeClematis manshurica Rupr.aerial parts(+)-epipinoresinol(-)-episyringaresinol2''-O-(2'''-methylbutyryl) isoswertisin

王威、刘小红、高华、张英华、李相成、范美玲、董方言

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青岛大学药学院,山东青岛266021

吉林省中医药科学院植物化学研究所,吉林长春 130012

毛茛科 东北铁线莲 地上部位 (+)-表松脂醇 (-)-表丁香树脂醇 2''-O-(2'''-甲基丁酰基)异当药苷

国家“十一五”科技支撑计划资助项目

2007BAI38B05

2014

10.7501/j.issn.0253-2670.2014.17.004

中草药
天津药物研究院,中国药学会

中草药

CSTPCDCSCD北大核心
影响因子：1.632
ISSN：0253-2670
年,卷(期)：2014.45(17)
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