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鼠曲草化学成分及其抗氧化活性研究

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目的 研究鼠曲草Gnaphalium affine的化学成分及其抗氧化活性.方法 采用硅胶柱色谱、Sephadex LH-20柱色谱等方法分离纯化,根据理化性质和波谱数据进行结构鉴定.测定了化合物1、3～11、16对DPPH自由基的清除活性.结果 从鼠曲草95％乙醇部位分离得到了17个化合物,分别鉴定为芹菜素(1)、二氢芹菜素(2)、木犀草素(3)、白杨素(4)、汉黄芩素(5)、豆甾醇(6)、β-谷甾醇(7)、熊果酸(8)、齐墩果酸(9)、19α-羟基熊果酸(10)、2α,3α,19α-trihydroxy-28-norurs12-ene (11)、α-香树酯醇乙酸酯(12)、β-香树酯醇乙酸酯(13)、patriscabratine(14)、aurantiamide acetate(15)、4'-hydroxydehydrokawain (16)、异香草醛(17).化合物1和3～5有显著的抗氧化活性.结论 化合物2、4、5、11～15、17为首次从该植物中分离得到.
Study on chemical constituents from Gnaphalium affine and their anti-oxidative activities
Objective To study the chemical constituents from Gnaphalium affine and their anti-oxidative activities.Methods Chemical constituents were isolated by column chromatography and semi-prepared HPLC,the structures were elucidated by spectral data and physicochemical properties.DPPH free radical scavenging activities of compounds 1,3-11,and 16 were determined.Results Seventeen compounds were isolated and respectively identified as apigenin (1),dihydroapigenin (2),luteolin (3),chrysin (4),wogonin (5),stimasterol (6),β-sitosterol (7),ursolic acid (8),oleanolic acid (9),19α-hydroxyl-oleanolic acid (10),2α,3α,19α-trihydroxy-28-norurs-12ene (11),α-amyrin acetate (12),β-amyrin acetate (13),patriscabratine (14),aurantiamide acetate (15),4'-hydroxydehydrokawain (16),and isovanillin (17).Compounds 1 and 3-5 had significant anti-oxidative activities.Conclusion Compounds 2,4,5,11-15,and 17 are isolated from G.affine for the frist time.

Gnaphalium affine D.Donapigeninluteolinchrysinwogoninα-amyrin acetate

白丽明、高鸿悦、马玉坤、张文治、张树军

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齐齐哈尔大学化学与化工学院,黑龙江齐齐哈尔 161006

齐齐哈尔医学院,黑龙江齐齐哈尔 161042

鼠曲草 芹菜素 木犀草素 白杨素 汉黄芩素 α-香树酯醇乙酸酯

黑龙江省自然科学基金资助项目黑龙江省教育厅资助项目教育部留学回国人员科研启动基金

B201314125215952009361341

2016

10.7501/j.issn.0253-2670.2016.04.004

中草药
天津药物研究院,中国药学会

中草药

CSTPCDCSCD北大核心
影响因子：1.632
ISSN：0253-2670
年,卷(期)：2016.47(4)
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