Water-soluble chemical constituents of Alhagi sparsifolia
Objective To study the water soluble chemical constituents of Alhagi sparsifolia.Methods Avariety of chromatographic techniques were used to separate and purify,and the structure of the compounds was identified by physicochemical properties,spectral data and X-single crystal diffraction,and the cytotoxicity of each compound to HeLa cells was tested.Results Twenty-one water-soluble compounds were isolated from the above-ground parts of A.sparsifolia after the process of extraction and were identified as drummondone A(1),drummondoneB(2),callyspongidipeptideA(3),cyclo(Pro-Leu)(4),4-(hydroxymethyl)phenol(5),cyclo(D)-Pro-(D)-Val(6),cyclo(L-pro-L-Leu)(7),blumenol A(8),(3S,4R)-3,4-dihydroxy-3-methyldihydrofuran-2(3H)-one(9),Isololiolide(10),dehydrovomifoliol(11),N-phenethylformamide(12),3-hydroxy-β-damascone(13),3,4-dihydroxy-3-methyldihydrofuran-2(3H)-one(14),cyclo(L-Pro-L-Ala)(15),proline(16),blumenol B(17),grasshopper ketone(18),N-(p-hydroxyphenethyl)(19),N-acetyltyramine(20),(+)-syringaresinol O-β-D-glucopyranoside(21),and compounds 1-21 were screened for anti-cervical cancer activity.Conclusion Compounds 1-7,9-20 were the first known compounds within the genus,and compounds 4,7 and 15 showed potential antitumor activity with median inhibition concentration(IC50)of(29.09±0.99),(31.51±1.89)and(28.25±0.65)μmol/L,respectively.
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