A selaginellin derivative with novel skeleton from Selaginella pulvinate
Objective To study the chemical constituents of the whole plants of Selaginella pulvinata. Methods The chemical constituents were isolated and purified by silica gel and Sephadex LH-20 column chromatography. The structures of the isolated compounds were identified based on physicochemical properties and spectroscopic data,and the cytotoxic activities against tested human cancer cell lines were evaluated by MTT method. Results A novel selaginellin derivative was isolated from the whole plants of S. pulvinata,which was identified as 9-hydroxy-3,4,13-tris(4-hydroxyphenyl)-7H-dibenzo[gh,pqr]tetraphen-7-one (1). Compound 1 showed potent inhibitory activity against human non-small cell lung cancer A549 cell with its half maximal inhibitory concentration of (16.29±1.44) μg/mL. Conclusion Compound 1 is a novel compound,named selaginbenzopyrene A,which shows selective cytotoxic activity.
Selaginella pulvinata (Hook. et Grev.) Maxim.selaginellin derivativeselaginbenzopyrene Astructure elucidationtumor cytotoxicity
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