垫状卷柏中1个新骨架的炔酚类化合物
A selaginellin derivative with novel skeleton from Selaginella pulvinate
吴永平 1段金廒 2曹园3
作者信息
- 1. 南京中医药大学附属医院江苏省中医院,江苏 南京 210029;江苏省药物研究所,江苏南京 210009
- 2. 南京中医药大学药学院,江苏省中药资源产业化过程协同创新中心/中药资源产业化与方剂创新药物国家地方联合工程研究中心,江苏 南京 210023
- 3. 南京中医药大学附属医院江苏省中医院,江苏 南京 210029;南京中医药大学药学院,江苏省中药资源产业化过程协同创新中心/中药资源产业化与方剂创新药物国家地方联合工程研究中心,江苏 南京 210023
- 折叠
摘要
目的 研究垫状卷柏Selaginella pulvinata全草的化学成分.方法 采用硅胶、Sephadex LH-20等多种柱色谱方法进行分离纯化,应用理化方法和波谱分析进行结构鉴定;采用MTT法测定化合物对人非小细胞肺癌A549细胞的抑制活性.结果 从垫状卷柏全草的95％乙醇提取物的醋酸乙酯部位分离得到1个新骨架类型的炔酚类化合物,鉴定为9-羟基-3,4,13-三(4-羟基苯基)-7H-二苯并[gh,pqr]四苯基-7-酮(1);化合物1对A549细胞显示出较强的抑制活性,其半数抑制浓度(half maximal inhibitory concentration,IC50)为(16.29±1.44)μg/mL.结论 化合物1为新化合物,命名为卷柏新酮,具有选择性细胞毒活性.
Abstract
Objective To study the chemical constituents of the whole plants of Selaginella pulvinata. Methods The chemical constituents were isolated and purified by silica gel and Sephadex LH-20 column chromatography. The structures of the isolated compounds were identified based on physicochemical properties and spectroscopic data,and the cytotoxic activities against tested human cancer cell lines were evaluated by MTT method. Results A novel selaginellin derivative was isolated from the whole plants of S. pulvinata,which was identified as 9-hydroxy-3,4,13-tris(4-hydroxyphenyl)-7H-dibenzo[gh,pqr]tetraphen-7-one (1). Compound 1 showed potent inhibitory activity against human non-small cell lung cancer A549 cell with its half maximal inhibitory concentration of (16.29±1.44) μg/mL. Conclusion Compound 1 is a novel compound,named selaginbenzopyrene A,which shows selective cytotoxic activity.
关键词
垫状卷柏/炔酚类化合物/卷柏新酮/结构鉴定/肿瘤细胞毒活性Key words
Selaginella pulvinata (Hook. et Grev.) Maxim./selaginellin derivative/selaginbenzopyrene A/structure elucidation/tumor cytotoxicity引用本文复制引用
出版年
2025
NETL
NSTL
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