Research progress on structures,activities of Wolfiporia hoelen polysaccharides and its structure-activity relationship
Fuling (Wolfiporia hoelen) polysaccharides (WHP),one of the main active substances in the sclerotia,mycelia and fermentation broth of Wolfiporia hoelen,are composed of more than ten monosaccharides linked through glucosidic bonds,and show a series of multiple activities including immune regulation,antitumor,anti-inflammatory,anti-oxidation,anti-depression,liver and stomach protection,memory enhancement,and sedative and hypnotic effects. However,the structure-activity relationship of WHP has not been fully elucidated. Moreover,the structures of WHP isolated from different parts of sclerotia of Wolfiporia hoelen or biosynthesized through different culture processes are also generally different. Consequently,classical total polysaccharide content analysis methods alone are insufficient for an objective evaluation of WHP's structures and activities. Therefore,it is essential to investigate the structure-activity relationships of WHP and to establish a systematic method for qualitative and quantitative analysis to improve its scientific application and development. This review systematically summarizes the structures and biological activities of WHP,and discusses the structure-activity relationship of WHP systemically,which could provide a comprehensive reference for the scientific analysis,structural modification,biosynthesis and comprehensive development of WHP.
Wolfiporia hoelen polysaccharidesstructure characterizationstructure modificationbiological activityrelationship between structure and activityimmune regulationantitumoranti-depressionsedation and hypnosis
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