Research progress on modified Simiao Yongan Decoction in treatment of sepsis and its application and development ideas and methods
Sepsis is a life-threatening multi-organ dysfunction caused by the host's response to the infection,and the pathogenesis involves the abnormalities and interactions of inflammatory response,vascular endothelium,coagulation,immunity,and microcirculation. Simiao Yongan Decoction (四妙勇安汤,SMYAD),a classic formula for treating digital gangrene caused by intense heat-toxicity,has been modified to exhibit various pharmacological effects such as anti-inflammatory,antioxidant,anticoagulant,and immunomodulatory activities. These modifications can ameliorate the dysfunction of multiple systems and organs during the development of sepsis,demonstrating a promising therapeutic effect. This paper systematically reviews the pathogenesis of sepsis,the research progress of modified SMYAD in treatment of sepsis,and the scientific problems faced by the subsequent application development,with a view to providing an important theoretical basis for application and development of the modified classic formula in treatment of sepsis and other critical illnesses.
sepsisSimiao Yongan Decoctionmodification and adaptationmulti-organ dysfunctionpharmacodynamic material basiscoagulation dysfunctions
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