Research progress on mechanism of Rehmannia glutinosa and its active components in intervention of knee osteoarthritis
Knee osteoarthritis (KOA) is a chronic joint disease that results in chondrocyte apoptosis,extracellular matrix degradation and abnormal loss of subchondral bone due to multiple factors. The treatment of KOA by traditional Chinese medicine has a long history and broad application prospect,which can effectively make up for the deficiency of modern medicine. Dihuang (Rehmannia glutinosa) and its active components catalpol,aucubin,salidroside,echinacoside and acteoside can interfere with KOA. By studying the mechanism of action of R. glutinosa extract and its monomer components in treating KOA,the research progress in inhibiting the secretion of pro-inflammatory cytokines,slowing down the degradation of cartilage matrix,promoting chondrocyte proliferation,inhibiting chondrocyte apoptosis,regulating chondrocyte autophagy,resisting oxidative stress injury,regulating the balance and cell differentiation of osteoblasts and osteoclasts to protect subchondral bone and relieve synovial tissue inflammation was reviewed. It provides theoretical basis for further research on R. glutinosa and its effective components to control KOA.
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