Phenolic compounds from Euphorbia fischeriana and their α-glucosidase inhibitory activity
Objective To investigate the chemical constituents of the roots of Euphorbia fischeriana and evaluate their α-glucosidase inhibitory activity.Methods A variety of chromatographic techniques were applied for the chemical separation and purification.Their structures were elucidated by a combination of IR,HR-ESI-MS and NMR spectra.PNPG method was performed to evaluate theα-glucosidase inhibitory activity.Results Eight phenolic compounds were isolated from the roots of E.fischeriana.Their structures were identified as methyl benzoate-4-O-α-L-arabinofuranosyl-(1→6)-β-D-glucopyranoside(1),phenethyl 6-O-α-L-arabinofuranosyl-β-D-glucopyranoside(2),scopoletin(3),corilagin(4),6-hydroxy-2-methoxyacetophenone-4-O-β-D-glucopyranoside(5),6-hydroxy-2-methoxyacetophenone-4-O-α-L-arabinofuranosyl-(1→6)-β-D-glucopyranoside(6),6-hydroxy-2-methoxyacetophenone-4-O-β-D-xylopyranosyl-(1→6)-β-D-glucopyranoside(7),erythroxyloside B(8).Conclusions Compound 1 is a new compound and named as euphfischcoside A,compounds 2-4 were isolated from E.fischeriana for the first time.Compounds 4 and 8 exhibit the considerable inhibition on α-glucosidase with the IC50 values of(7.44±3.95)μmol/L and(134.40±30.27)μmol/L,respectively.
Euphorbia fischeriana Steud.phenolic acidglucosidesα-glucosidaseeuphfischcoside Aphenethyl 6-O-α-L-arabino-furanosyl-β-D-glucopyranosidescopoletin
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