Research progress on plant-derived extracellular vesicles-like particles in prevention and treatment of intestinal and liver diseases from perspective of"intestinal-hepatic dialogue"
Plant-derived extracellular vesicles(PDEVs)are nano-sized vesicles released by plant cells,which contain protein,lipids,nucleic acids and other bioactive substances.PDEVs not only participate in the regulation of physiological and pathological processes of the body,such as cross-border communication,cell proliferation and differentiation,immune regulation,and inflammatory reaction but also can overcome the biological barrier as a drug carrier to target the lesion and play a key role in prognosis of the disease.With the in-depth study of PDEVs,their application potential in prevention and treatment of intestinal and liver diseases has gradually emerged.However,the potential mechanism of how PDEVs can play a therapeutic role through the intestinal-hepatic axis is not clear.Given PDEVs'outstanding advantages such as good natural targeting and biocompatibility,in this paper,the molecular mechanism of PDEVs in preventing and treating intestinal-hepatic disease is summarized and discussed from perspective of intestinal-hepatic axis,to provide new ideas and methods for research of PDEVs in treating intestinal-hepatic disease.
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