从"肠-肝对话"角度探究植物来源细胞外囊泡样颗粒防治肠肝疾病的研究进展
Research progress on plant-derived extracellular vesicles-like particles in prevention and treatment of intestinal and liver diseases from perspective of"intestinal-hepatic dialogue"
黄志远 1胡静雯 1卢倩 1马洁 1贺欣雨 1代薪钰 1杨珅珅 1于海洋1
作者信息
- 1. 天津中医药大学中药学院,天津 301617
- 折叠
摘要
植物来源的细胞外囊泡(plant-derived extracellular vesicles,PDEVs)是植物细胞释放的纳米级囊泡,内含蛋白质、脂质、核酸等生物活性物质,不仅参与机体生理病理过程的调控,如跨界通讯、细胞增殖分化、免疫调节和炎症反应等,还可克服生物屏障作为药物载体靶向病变部位,对疾病的转归起到关键作用.随着对PDEVs研究的深入,其在肠肝疾病防治的应用潜力逐渐显现.然而关于PDEVs如何通过肠-肝轴发挥治疗作用的潜在机制尚未明确,鉴于PDEVs具备良好的自然靶向性、生物相容性等突出优势,从肠-肝轴的角度切入,在肠道、肝脏及二者之间相互调节和通信层面上对PDEVs防治肠肝疾病的分子作用机制进行总结探讨,为PDEVs治疗肠肝疾病的研究提供新的思路与方法.
Abstract
Plant-derived extracellular vesicles(PDEVs)are nano-sized vesicles released by plant cells,which contain protein,lipids,nucleic acids and other bioactive substances.PDEVs not only participate in the regulation of physiological and pathological processes of the body,such as cross-border communication,cell proliferation and differentiation,immune regulation,and inflammatory reaction but also can overcome the biological barrier as a drug carrier to target the lesion and play a key role in prognosis of the disease.With the in-depth study of PDEVs,their application potential in prevention and treatment of intestinal and liver diseases has gradually emerged.However,the potential mechanism of how PDEVs can play a therapeutic role through the intestinal-hepatic axis is not clear.Given PDEVs'outstanding advantages such as good natural targeting and biocompatibility,in this paper,the molecular mechanism of PDEVs in preventing and treating intestinal-hepatic disease is summarized and discussed from perspective of intestinal-hepatic axis,to provide new ideas and methods for research of PDEVs in treating intestinal-hepatic disease.
关键词
植物源EVs样颗粒/肠-肝轴/肠道疾病/肝脏疾病/肠道菌群/药物载体Key words
plant-derived EVs-like particles/intestinal-hepatic axis/intestinal disease/liver disease/intestinal flora/drug carrier引用本文复制引用
出版年
2025
NETL
NSTL
万方数据