中药及其活性成分抗黑色素瘤转移的研究进展
Research progress on anti-melanoma metastasis of traditional Chinese medicine and its active ingredients
杨浩林 1鲍宁 1李保宏 2刘辉 2马嘉翼 1蔡梅超 1李肖2
作者信息
- 1. 山东中医药大学药学院,山东济南 250355
- 2. 山东中医药大学中医药创新研究院,山东济南 250355
- 折叠
摘要
黑色素瘤是高度易于转移的肿瘤之一,其主要的转移器官有肺、淋巴结、脑等.黑色素瘤的转移与上皮-间质转化(epithelial-mesenchymal transition,EMT)、代谢重编程及免疫微环境密切相关.EMT使黑色素瘤细胞变得更具侵袭性,同时伴随代谢重编程,为细胞提供能量支持,助长免疫逃逸,促使肿瘤发展和转移.中药可通过抑制EMT过程、调控代谢重编程及重塑免疫微环境发挥抗黑色素瘤转移的作用.通过系统综述黑色素瘤的转移过程及中药抗黑色素瘤转移的研究,为中药抗黑色素瘤研究提供科学依据和理论基础.
Abstract
Melanoma is one of the highly metastatic tumors.The main metastatic organs are lung,lymph nodes,brain and so on.The metastasis of melanoma is closely related to epithelial-mesenchymal transition(EMT),metabolic reprogramming and immune microenvironment.EMT makes melanoma cells more invasive,accompanied by metabolic reprogramming,providing energy support for cells,promoting immune escape,and promoting tumor development and metastasis.Traditional Chinese medicine plays a role in anti-melanoma metastasis by inhibiting EMT process,regulating metabolic reprogramming and remodeling immune microenvironment.This paper systematically reviews the metastasis process of melanoma and the research progress of traditional Chinese medicine against melanoma metastasis,and provides scientific basis and theoretical basis for the study of traditional Chinese medicine against melanoma.
关键词
中药/活性成分/黑色素瘤转移/上皮-间质转化/代谢重编程/免疫微环境Key words
traditional Chinese medicine/active ingredients/melanoma metastasis/epithelial-mesenchymal transition/metabolic reprogramming/immune microenvironment引用本文复制引用
出版年
2025
NETL
NSTL
万方数据