组学新技术在中药毒性研究中的应用进展
Application progress on new omics technology in toxicity evaluation of traditional Chinese medicine
李丁 1王婉瑩 2孙璐 3雷艳 4孔娇 5何涛 6马恺悦 7刘传鑫2
作者信息
- 1. 郑州大学附属肿瘤医院(河南省肿瘤医院)药学部,河南郑州 450008
- 2. 河南科技大学临床医学院,河南科技大学第一附属医院内分泌代谢中心,河南省罕见病重点实验室,洛阳市临床多组学与转化医学重点实验室,河南洛阳 471003
- 3. 山西中医药大学中药与食品工程学院,山西晋中 030619
- 4. 山西医科大学第一医院乳腺科,山西太原 030001
- 5. 浙江大学药学院药物代谢和药物分析研究所,浙江 杭州 310058
- 6. 浙江大学药学院药物信息学研究所,浙江 杭州 310058
- 7. 北京同仁堂股份有限公司同仁堂制药厂,北京 102600
- 折叠
摘要
整合多组学策略为中药安全性评价开辟了新的研究视角,单细胞转录组学、蛋白质修饰组学、代谢组学、影像组学等前沿组学技术实现了从分子、细胞、组织到系统乃至整体不同层面揭示中药的毒性效应机制,帮助识别中药潜在毒性成分并发现特征生物标志物.基于中国知网、PubMed、Web of Science等权威数据库检索近10年与多组学技术和中药安全性评价/毒性研究的相关文献并进行梳理归纳.回顾中药毒性研究现状,系统阐述并总结各类组学新技术在中药毒性研究中的应用进展,为推动多组学联合应用作为中药毒性研究新策略提供参考.未来高通量数据处理技术的进步有望推动多组学技术为中药安全性评价体系的完善作出更大贡献.
Abstract
The integration of multi-omics strategies has opened up a new research perspective for the safety evaluation of traditional Chinese medicine.Cutting-edge omics technologies such as single-cell transcriptomics,protein modification omics,metabolomics and imaging omics have realized the mechanism of toxic effects of traditional Chinese medicine(TCM)from different levels of molecules,cells,tissues,systems and even the whole,helping to identify potential toxic components of TCM and discover characteristic biomarkers.Based on CNKI,PubMed,Web of Science and other authoritative databases,literature related to multi-omics technology and TCM safety evaluation/toxicity studies in the past 10 years was searched and summarized.This paper reviewed the status of toxicity research of TCM,systematically expounded and summarized the application progress of various new omics technologies in toxicity research of TCM,and provided reference for promoting the combined application of multi-omics as a new strategy for toxicity research of traditional Chinese medicine.In the future,the progress of high-throughput data processing technology is expected to promote multi-omics technology to make greater contributions to the improvement of traditional Chinese medicine safety evaluation system.
关键词
组学技术/多组学策略/中药/毒性/安全性评价/单细胞转录组学、蛋白质修饰组学、代谢组学、影像组学Key words
omics technology/multi-omics strategy/traditional Chinese medicine/toxicity/safety evaluation/single-cell transcriptomics/protein modification omics/metabolomics/imaging omics引用本文复制引用
出版年
2025
NETL
NSTL
万方数据