整合多组学策略为中药安全性评价开辟了新的研究视角，单细胞转录组学、蛋白质修饰组学、代谢组学、影像组学等前沿组学技术实现了从分子、细胞、组织到系统乃至整体不同层面揭示中药的毒性效应机制，帮助识别中药潜在毒性成分并发现特征生物标志物。基于中国知网、PubMed、Web of Science等权威数据库检索近10年与多组学技术和中药安全性评价/毒性研究的相关文献并进行梳理归纳。回顾中药毒性研究现状，系统阐述并总结各类组学新技术在中药毒性研究中的应用进展，为推动多组学联合应用作为中药毒性研究新策略提供参考。未来高通量数据处理技术的进步有望推动多组学技术为中药安全性评价体系的完善作出更大贡献。
Application progress on new omics technology in toxicity evaluation of traditional Chinese medicine
The integration of multi-omics strategies has opened up a new research perspective for the safety evaluation of traditional Chinese medicine.Cutting-edge omics technologies such as single-cell transcriptomics,protein modification omics,metabolomics and imaging omics have realized the mechanism of toxic effects of traditional Chinese medicine(TCM)from different levels of molecules,cells,tissues,systems and even the whole,helping to identify potential toxic components of TCM and discover characteristic biomarkers.Based on CNKI,PubMed,Web of Science and other authoritative databases,literature related to multi-omics technology and TCM safety evaluation/toxicity studies in the past 10 years was searched and summarized.This paper reviewed the status of toxicity research of TCM,systematically expounded and summarized the application progress of various new omics technologies in toxicity research of TCM,and provided reference for promoting the combined application of multi-omics as a new strategy for toxicity research of traditional Chinese medicine.In the future,the progress of high-throughput data processing technology is expected to promote multi-omics technology to make greater contributions to the improvement of traditional Chinese medicine safety evaluation system.
omics technologymulti-omics strategytraditional Chinese medicinetoxicitysafety evaluationsingle-cell transcriptomicsprotein modification omicsmetabolomicsimaging omics
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