Research progress of multiple regulatory effects of baicalin and baicalein on colorectal cancer
The prevalence of colorectal cancer(CRC)is increasing globally,and despite some advances were got in related treatments,CRC still ranks among the top three in terms of mortality rate due to the problems of drug resistance and low efficiency.There is increasing evidence that baicalin and baicalein,extracts of the traditional Chinese medicine Scutellaria baicalensis,as novel small-molecule inhibitors,not only have good anticolorectal cancer effects,but also are not easy to induce drug resistance in cancer cells.In this paper,a systematic review of the current research status of baicalin and baicalein,two flavonoids,in the treatment of colorectal cancer was presented,reviewing and discussing their potential roles and related mechanisms in inhibiting the proliferation and invasion and metastasis of cancer cells,inducing the death of cancer cells,and regulating the tumour microenvironment(TME),with the aim of providing new ideas for the therapeutic protocols of CRC.
baicalinbaicaleincolorectal cancerapoptosismechanism of action
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