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山茱萸化学成分和药理作用的研究进展

Research progress on chemical composition and pharmacology of Cornus officinalis

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山茱萸Cornus officinalis作为中国传统重要中药品种之一,资源丰富,其成分、药理作用多样,具有极大药用价值.目前从山茱萸中分离鉴定出多种化学物质,包括环烯醚萜类及其苷、三萜类、有机酸类、黄酮类、多糖等;药理作用主要有抗肿瘤、降血糖、保护神经元、抗氧化和抗炎等.通过检索近 20 年国内外相关文献,对山茱萸的主要化学成分、药理作用进行综述,为探究山茱萸的现代临床作用的机制方面提供新的思路和方向.
Cornus officinalis,as one of the important traditional Chinese medicinal varieties in China,is rich in resources,with a variety of constituents,pharmacological effects and great medicinal value.At present,a variety of chemical substances have been isolated and identified from C.officinalis,including iridoid terpenoids and their glycosides,triterpenoids,organic acids,flavonoids,polysaccharides,etc.;and the pharmacological effects mainly include antitumor,hypoglycemia,neuron protection,antioxidant and anti-inflammatory.In this manuscript,the main chemical constituents and pharmacological effects of C.officinalis are reviewed by searching the relevant literature at home and abroad in the past 20 years,with a view to providing new ideas and directions for the study of C.officinalis'mechanism in modern clinical practice.

Cornus officinalis Sieb.et Zucc.iridoid terpenoidstanninsflavonoidslowering blood sugaranti-tumorneuroprotectionanti-inflammatoryantioxidant

汪嘉俊、王泽萍、王雪莲、贾旨乐、明家和、曹岗、韩欣

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浙江中医药大学药学院,浙江 杭州 311400

山茱萸 环烯醚萜类 鞣质类 黄酮类 降血糖 抗肿瘤 神经保护 抗炎 抗氧化

2025

中草药
天津药物研究院,中国药学会

中草药

北大核心
影响因子:1.632
ISSN:0253-2670
年,卷(期):2025.56(3)