Progress of researches on mechanisms of acupuncture underlying improvement of cerebral ischemia-reperfusion injury by regulating calcium overload
Ischemic stroke is currently the most common type of stroke,and the key pathological link is cerebral ischemia-reperfusion injury(CIRI),while the key factor leading to apoptosis and necrosis of ischemic nerve cells is cal-cium overload.Current studies have confirmed that acupuncture therapy has a good modulating effect on calcium ho-meostasis and can reduce cerebral ischemia-reperfusion induced damage of neuronal cells by inhibiting calcium over-load.After reviewing the relevant literature published in the past 15 years,we find that acupuncture plays a role in regu-lating the pathological mechanism of calcium overload after CIRI by inhibiting the opening of connexin 43 hemichannels,regulating the intracellular free calcium ion concentration,suppressing the expression of calmodulin,and blocking the func-tion of L-type voltage-gated calcium channels,thereby inhibiting calcium overload,regulating calcium homeostasis and antagonizing neuronal damage resulted from cerebral ischemia-reperfusion,which may provide ideas for future research.
国家科技期刊平台
NSTL
万方数据
