Correlation between spread through air space and clinicopathological risk factors for lung adenocarcinoma
Objective To investigate the significance of spread through air space(STAS)in lung adenocarcinoma and its correlation with clinicopathological risk factors.Methods A total of 228 patients with lung adenocarcinoma who underwent surgical resection in Zhuozhou Hospital and Hebei Yizhou Cancer Hospital from October 2015 to October 2022 were enrolled.STAS status was accessed by hematoxylin-eosin(HE)staining to analyze the association with clinicopathological risk factors.Results STAS was associated with sex,smoking,histological type,T stage,lymph node metastasis,vascular invasion and lung membrane invasion(P＜0.05),but not with age.Survival analysis found that overall survival of patients with STAS was lower than that of patients without STAS(P＜0.05).Conclusion STAS has an important value in the prognosis of patients with lung adenocarcinoma.The combination of STAS and clinicopathological risk factors can improve the accuracy and reliability of prognosis assessment of lung adenocarcinoma.It is recommended to include this index in routine pathology reports to provide a more scientific and comprehensive basis for the treatment and prognosis assessment of lung adenocarcinoma patients.
Spread through air spaceLung cancerClinicopathological risk factorsSpread through air spacePrognosis
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