Clinicopathological characteristics of primary gastric natural killer/T-cell lymphoma and differential diagnosis:report of four cases and review of literature
Objective Primary gastric natural killer/T-cell(NK/T-cell)lymphomais is extremely rare.This article summarized its clinicopathological features,differential diagnosis and prognosis to improve the understanding of this disease.Methods All the cases diagnosed as primary gastric NK/T-cell lymphoma from 2014.1-2023.3 in the First Affiliated Hospital of Air Force Military Medical University were retrospectively reviewed.Results Four patients with primary gastric NK/T-cell lymphoma ranged in age from 48 to 71 years(median age was 61 years),with a male to female ratio of 1∶1.Histologically,the tumor cells were mainly medium sized lymphoid cells with irregular,twisted or angular nuclei,obvious nucleoli,mitotic figures,apoptotic bodies and nuclear debris,and often vascular invasion,accompanied by ulceration and necrosis.Immunohistochemical staining showed positive tumor cells of CD3(4/4),CD56(3/4),TIA(4/4)),Granzyme B(3/4)and CD30(3/4),Ki-67 proliferation index 50％-80％.In situ hybridization EBER was positive in all 4 cases.Conclusion Primary gastric NK/T cell lymphoma is rare and should not be missed or misdiagnosed.The prognosis of primary gastric NK/T cell lymphoma requires more follow-up observation,but the expression of CD30 can provide new hope for some patients with refractory recurrence.
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