Monomorphic epitheliophilic intestinal T-cell lymphoma:a clinicopathological study of three cases
Objective To investigate the clinicopathological features,diagnosis and differential diagnosis of monomorphic epitheliophilic intestinal T-cell lymphoma(MEITL)in order to improve the understanding of rhis type of lymphoma.Methods The clinical data of 3 cases of MEITL diagnosed in our hospital were collected,histological and immunohistochemical observation were performed,and relevant literature was reviewed to summarize the main points of diagnosis and differential diagnosis of MEITL.Results Under the microscope,lymphocytes permeated the entire intestinal wall,intestinal mucosal erosion accompanied by ulcer formation,and lymphoepithelial lesions were observed.Tumor cells were relatively uniform,medium in size,visible nucleoli,irregular cell membranes,pale cytoplasm,and mitotic figures and nuclear fragmentation were observed.Immunohistochemical analysis showed that CD3,CD2,CD7,CD8,CD56 and TIA-1 were expressed in all 3 cases,while CD20,PAX-5,CD30,EBER and H3k36me were not expressed in all cases.Ki67 index was about 70％,and p53 was weakly positive.Conclusion MEITL is relatively rare,the clinical symptoms are not specific,and thus the early stage is easy to miss diagnosis;the late stage is easily confused with other malignant tumors,but most of the postoperative pathological diagnosis is clear.
Monomorphic epitheliophilic intestinal T cell lymphomaDiagnosisDifferential diagnosisLymphomaTherapy
NETL
NSTL
万方数据
