Clinical significance of bone marrow biopsy and IFI16 expression in patients with primary multiple myeloma
Objective To investigate the clinical significance of bone marrow biopsy pathologic analysis and interferon-induced protein 16(IFI16)expression in patients with primary multiple myeloma(MM).Methods The expression level of IFI16 was detected by pathologic analysis in 108 patients with initial onset of MM.The pathologic result and prognostic factors of bone marrow biopsy were analyzed by Logistic and ROC.Results In 106 MM patients,the number of proliferative model types was the highest,and the number of maturity type I was the highest.The proportion of age ≥60 years in the poor prognosis group,the proportion of time from diagnosis to treatment ≥ 3 months,the proportion of ISS stageⅢ,the proportion of maturity type Ⅲ,the proportion of diffuse type and the proportion of IFI16 high expression in the poor prognosis group were higher than those in the good prognosis group.Logistic analysis showed that except for ≥ 3 months from diagnosis to treatment,all the other risk factors were independent of MM(P＜0.05).ROC showed that the AUC predicted by the combination of histopathology and IFI16 was higher than that predicted by alone.Conclusion In the pathology of initial onset of MM,patients with maturity type Ⅲ,diffuse type and high expression of IFI16 have poor prognosis.
Multiple myelomaPathologic analysisInterferon-induced protein 16Prognosis
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