Ovarian seromucinous tumours:a clinicopathological analysis and molecular characteristics of seven cases
Objective To elucidate the clinicopathologic characteristics,immunophenotype,differential diagnosis and molecular characteristics of ovarian seromucinous tumours.Methods Clinicopathological characteristics of 7 cases of ovarian seromucinous tumours were analyzed.Immunohistochemical and molecular detection were performed,and relevant literatures were reviewed.Results The age of the 7 patients ranged from 25 to 56 years.The median age of patients was 42 years.The maximum dimension of these tumours ranged from 2.8 to 13.0 cm.One case were bilateral ovarian lesion and six cases of unilateral.All 7 tumors contained endocervical-like mucinous cells and Mullerian epithelium cells.The tumors exhibited papillary architectures,cribriform and micropapillary architectures.Massive neutrophilic infiltration could be seen in the stroma.Destructive infiltration and significant cellular heterogeneity suggested malignancy.Immunohistochemically,ER,PR and CK7 were positive in 7/7 cases.PAX-8 was positive in 5/7 cases and PAX-2 was positive in 3/7 cases.7 cases had PTEN deletion;Ki-67 positivity index was 5％-40％;2 cases suggest that BRAF,PIK3CA,PIK3R1 and PTEN gene mutations,and no abnormalities were seen in ARID1A,Tp53,BRCA1,and BRCA2.All cases were microsatellite stability.Conclusion Ovarian seromucinous tumours possesses distinctive pathomorphological features.Immunophenotypical and molecular characteristics overlap with endometrioid tumors.It has relatively better prognosis.
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