Clinicopathological changes of breast acinar cell carcinoma before and after neoadjuvant chemotherapy
Objective To investigate the clinicopathological features,treatment and prognosis of breast acinic cell carcinoma(ACCA)before and after neoadjuvant chemotherapy,in order to improve the understanding of it.Methods The clinicopathological features of one case of ACCA breast diagnosed in our hospital were retrospectively analyzed,and the relevant literature was reviewed.Results The patient is a 47-year-old female.Before chemotherapy,the tumor tissues showed a variety of morphologies,which distributed in the form of nests,vesicular or cords,and grew infiltratively into the surrounding fibrous adipose tissue.The carcinoma cells were pleomorphic,with coarse chromatin and basophilic cytoplasm.After chemotherapy,only vesicular or microadenoid structures were observed,and eosinophilic colloid secretions were observed in the glandular cavity.The morphology of carcinoma cells was mild,the nuclei were small and uniform,and the cytoplasm was clear.Interstitial fibrosis and numerous lymphocyte infiltration were also noted.Conclusion During neoadjuvant chemotherapy in breast ACCA,moderately-poorly differentiated components(solid nest-like and string-like structures)are more sensitive to chemotherapy than well differentiated components(normal vesicular structures).ACCA needs to be differentiated from secretory carcinoma,apocrine adenocarcinoma,eosinophilic carcinoma and other diseases.
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